Stabilized dynorphin derivatives for modulating antinociceptive activity in morphine tolerant rats: Effect of different routes of administration

• Published in: The AAPS journal Vol. 6; no. 4; pp. 68 - 73
• Main Authors: Brugos, Boglarka, Arya, Vikram, Hochhaus, Guenther
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2004

Dynorphins, such as dynorphin A(1--13) (Dyn A(1--13)), have been shown to enhance analgesia in morphine-tolerant animals, despite their very short half-life after intravenous administration. The potential use of dynorphins in humans is therefore of interest. This laboratory has recently evaluated th...