TSG101 Physically Interacts with Linear Ubiquitin Chain Assembly Complex (LUBAC) and Upregulates the TNFα-Induced NF-κB Activation

Linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin E3 ligase complex composed of HOIP, HOIL-1L, and SHARPIN that catalyzes the formation of linear/M1- linked ubiquitin chain. It has been shown to play a pivotal role in the nuclear factor (NF)-κB signaling induced by proinflammatory stimu...

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Published inMolecules and cells Vol. 46; no. 7; pp. 430 - 440
Main Authors Kim, Eunju, Cho, Hyunchu, Lee, Gaeul, Baek, Heawon, Lee, In Young, Choi, Eui-Ju
Format Journal Article
LanguageEnglish
Published United States Korean Society for Molecular and Cellular Biology 31.07.2023
Subjects
Genes, Regulator
NF-kappa B
Signal Transduction
Tumor Necrosis Factor-alpha - pharmacology
Ubiquitins
nuclear factor-κB
tumor susceptibility gene 101
linear ubiquitin chain assembly complex
tumor necrosis factor α
HOIL-1-interacting protein
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Abstract Linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin E3 ligase complex composed of HOIP, HOIL-1L, and SHARPIN that catalyzes the formation of linear/M1- linked ubiquitin chain. It has been shown to play a pivotal role in the nuclear factor (NF)-κB signaling induced by proinflammatory stimuli. Here, we found that tumor susceptibility gene (TSG101) physically interacts with HOIP, a catalytic component of LUBAC, and potentiates LUBAC activity. Depletion of TSG101 expression by RNA interference decreased TNFα-induced linear ubiquitination and the formation of TNFα receptor 1 signaling complex (TNFRSC). Furthermore, TSG101 facilitated the TNFα-induced stimulation of the NF-κB pathway. Thus, we suggest that TSG101 functions as a positive modulator of HOIP that mediates TNFα-induced NF-κB signaling pathway.
AbstractList Linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin E3 ligase complex composed of HOIP, HOIL-1L, and SHARPIN that catalyzes the formation of linear/M1-linked ubiquitin chain. It has been shown to play a pivotal role in the nuclear factor (NF)-κB signaling induced by proinflammatory stimuli. Here, we found that tumor susceptibility gene (TSG101) physically interacts with HOIP, a catalytic component of LUBAC, and potentiates LUBAC activity. Depletion of TSG101 expression by RNA interference decreased TNFα-induced linear ubiquitination and the formation of TNFα receptor 1 signaling complex (TNF-RSC). Furthermore, TSG101 facilitated the TNFα-induced stimulation of the NF-κB pathway. Thus, we suggest that TSG101 functions as a positive modulator of HOIP that mediates TNFα-induced NF-κB signaling pathway.
Linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin E3 ligase complex composed of HOIP, HOIL-1L, and SHARPIN that catalyzes the formation of linear/M1- linked ubiquitin chain. It has been shown to play a pivotal role in the nuclear factor (NF)-κB signaling induced by proinflammatory stimuli. Here, we found that tumor susceptibility gene (TSG101) physically interacts with HOIP, a catalytic component of LUBAC, and potentiates LUBAC activity. Depletion of TSG101 expression by RNA interference decreased TNFα-induced linear ubiquitination and the formation of TNFα receptor 1 signaling complex (TNFRSC). Furthermore, TSG101 facilitated the TNFα-induced stimulation of the NF-κB pathway. Thus, we suggest that TSG101 functions as a positive modulator of HOIP that mediates TNFα-induced NF-κB signaling pathway.
Author Kim, Eunju
Lee, In Young
Choi, Eui-Ju
Lee, Gaeul
Baek, Heawon
Cho, Hyunchu
AuthorAffiliation 2 GNT Science & Technology Center for Health, GNT Pharma Co., Ltd., Yongin 17096, Korea
1 Laboratory of Cell Death and Human Diseases, Department of Life Sciences, Korea University, Seoul 02841, Korea
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Issue 7
Keywords nuclear factor-κB
tumor susceptibility gene 101
linear ubiquitin chain assembly complex
tumor necrosis factor α
HOIL-1-interacting protein
Language English
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Snippet Linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin E3 ligase complex composed of HOIP, HOIL-1L, and SHARPIN that catalyzes the formation of...
SourceID pubmedcentral
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 430
SubjectTerms Genes, Regulator
NF-kappa B
Signal Transduction
Tumor Necrosis Factor-alpha - pharmacology
Ubiquitins
Title TSG101 Physically Interacts with Linear Ubiquitin Chain Assembly Complex (LUBAC) and Upregulates the TNFα-Induced NF-κB Activation
URI https://www.ncbi.nlm.nih.gov/pubmed/37431163
https://pubmed.ncbi.nlm.nih.gov/PMC10336271
Volume 46
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