Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth

• Published in: Clinical cancer research Vol. 28; no. 11; pp. 2409 - 2424
• Main Authors: Madhavan, Krishna, Balakrishnan, Ilango, Lakshmanachetty, Senthilnath, Pierce, Angela, Sanford, Bridget, Fosmire, Susan, Elajaili, Hanan B, Walker, Faye, Wang, Dong, Nozik, Eva S, Mitra, Siddhartha S, Dahl, Nathan A, Vibhakar, Rajeev, Venkataraman, Sujatha
• Format: Journal Article
• Language: English
• Published: United States 01.06.2022

Tumor relapse after radiotherapy is a major hurdle in treating pediatric H3K27M-mutant diffuse midline gliomas (DMG). Radiotherapy-induced stress increases association of BCL2 family of proteins with BH3 pro-apoptotic activators preventing apoptosis. We hypothesized that inhibition of radiotherapy-i...