Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants

• Published in: Medicinal chemistry research Vol. 33; no. 10; pp. 1938 - 1953
• Main Authors: Du, Wen-Rong, Wei, Ben-Ben, Guo, Xin-Yuan, Lan, Yong, Shang, Pan-Pan, Wang, Yi-Xuan, Zhou, Xue-Wei, Wang, Xiao-Ke, Ma, Zheng-Yue
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2024; Springer Nature B.V
• Subjects: Acetylcholinesterase; Alzheimer's disease; Antioxidants; Ascorbic acid; Biochemistry; Biological activity; Biological effects; Biological properties; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Cholinesterase inhibitors; Drug development; Enzyme kinetics; Galantamine; Inhibitors; Inorganic Chemistry; Medicinal Chemistry; Molecular docking; Molecular properties; Neurodegenerative diseases; Oral administration; Original Research Article; Pharmacology/Toxicology; Pyrazine; Scavenging; Stability; Synthesis; Molecular docking study; Acetylcholinesterase inhibitor; Molecular dynamics simulation; Alzheimer’s disease; Antioxidant

A series of 8-(piperazin-1-yl)imidazo[ 1,2-a ]pyrazine derivatives were designed and synthesized as acetylcholinesterase inhibitors (AChEIs) and antioxidants for the treatment of Alzheimer’s disease (AD). Moreover, the biological evaluation results demonstrated that these synthesized compounds exhib...