Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants - Du, Wen-Rong; Wei, Ben-Ben; Guo, Xin-Yuan; Lan, Yong; Shang, Pan-Pan; Wang, Yi-Xuan; Zhou, Xue-Wei; Wang, Xiao-Ke; Ma, Zheng-Yue (Medicinal chemistry research, 2024)
Keywords: Acetylcholinesterase; Alzheimer's disease; Antioxidants; Ascorbic acid; Biochemistry; Biological activity; Biological effects; Biological properties; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Cholinesterase inhibitors; Drug development; Enzyme kinetics; Galantamine; Inhibitors; Inorganic Chemistry; Medicinal Chemistry; Molecular docking; Molecular properties; Neurodegenerative diseases; Oral administration; Original Research Article; Pharmacology/Toxicology; Pyrazine; Scavenging; Stability; Synthesis; Molecular docking study; Acetylcholinesterase inhibitor; Molecular dynamics simulation; Alzheimer’s disease; Antioxidant