Antioxidant Activity, Antiproliferative Activity, Antiviral Activity, NO Production Inhibition, and Chemical Composition of Essential Oils and Crude Extracts of Leaves, Flower Buds, and Stems of Tetradenia riparia
The chemical composition of extracts (CEs) and essential oils (EOs) from leaves, flower buds, and stems was analyzed. Antiproliferative activity against tumor cell lines, NO production inhibition, and antioxidant and antiviral activities were assessed. The CEs contained flavonoids, phenolic acids, c...
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Published in | Pharmaceuticals (Basel, Switzerland) Vol. 17; no. 7; p. 888 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
04.07.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The chemical composition of extracts (CEs) and essential oils (EOs) from
leaves, flower buds, and stems was analyzed. Antiproliferative activity against tumor cell lines, NO production inhibition, and antioxidant and antiviral activities were assessed. The CEs contained flavonoids, phenolic acids, coumarins, and saturated fatty acids. The EOs included monoterpenes, oxygenated sesquiterpenes, and diterpenes. NO production inhibition ranged from 76 to 247 µg mL
, and antiproliferative activity exhibited GI
between 20 and >204 µg mL
, with low cytotoxicity (SI: 1.08 to 4.75). Reactive oxygen species inhibition ranged from 45 to 82%. Antioxidant activity varied when determined by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay (IC
: 0.51 to 8.47 mg mL
) and ferric reducing antioxidant power (0.35 to 0.81 µM ferrous sulfate per mg). The reduction in β-carotene-linoleic acid co-oxidation varied between 76.13 and 102.25%. The total phenolic content of CEs and EOs was 10.70 to 111.68 µg gallic acid mg
. Antiviral activity against herpes simplex virus type 1 (HSV-1) showed an EC
between 9.64 and 24.55 µg mL
and an SI between 8.67 and 15.04. Leaf EOs exhibited an EC
of 9.64 µg mL
and an SI of 15.04. Our study unveils the diverse chemical composition and multifaceted pharmacological properties of
, demonstrating its potential as a valuable source of bioactive compounds for therapeutic applications. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1424-8247 1424-8247 |
DOI: | 10.3390/ph17070888 |