Advances in research of ursolic acid and its derivatives as potential drug candidates against various types of lung cancers

• Published in: Medicinal chemistry research Vol. 32; no. 11; pp. 2279 - 2298
• Main Authors: Song, Li, Dai, Ling, Tan, Yan, Jiang, Kailin, Wei, Xueni, Hu, Yufei, Hu, Yalin, Lin, Jieying, Yao, Xu, Mi, Pengbing, Zheng, Xing
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2023; Springer Nature B.V
• Subjects: Bioavailability; Biochemistry; Biological activity; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Drug development; Functional groups; Inorganic Chemistry; Lung cancer; Medicinal Chemistry; Pharmacology/Toxicology; Review Article; Toxicity; Ursolic acid; Ursolic acid derivatives; IC; Structure–activity relationship; Mechanism; Anti-lung cancer activities

As one of the most common mortal diseases, the development of anti-lung cancer drugs is never stopped. Ursolic acid (UA) is a pentacyclic triterpenoid with significant anti-lung cancer activity and low toxicity. The bottleneck of UA in clinical application is poor water solubility and bioavailabilit...