Advances in research of ursolic acid and its derivatives as potential drug candidates against various types of lung cancers
As one of the most common mortal diseases, the development of anti-lung cancer drugs is never stopped. Ursolic acid (UA) is a pentacyclic triterpenoid with significant anti-lung cancer activity and low toxicity. The bottleneck of UA in clinical application is poor water solubility and bioavailabilit...
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| Published in | Medicinal chemistry research Vol. 32; no. 11; pp. 2279 - 2298 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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New York
Springer US
01.11.2023
Springer Nature B.V |
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| Abstract | As one of the most common mortal diseases, the development of anti-lung cancer drugs is never stopped. Ursolic acid (UA) is a pentacyclic triterpenoid with significant anti-lung cancer activity and low toxicity. The bottleneck of UA in clinical application is poor water solubility and bioavailability. Until now, many novel UA derivatives have been developed to overtake these problems. In this paper, the relationship between the structure and activity of different functional groups was discussed. All anti-lung cancer ursolic acid derivatives were reviewed, and their biological activity and structure–activity relationship were described. The research progress of UA derivatives against various types of lung cancer was reviewed. |
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| AbstractList | As one of the most common mortal diseases, the development of anti-lung cancer drugs is never stopped. Ursolic acid (UA) is a pentacyclic triterpenoid with significant anti-lung cancer activity and low toxicity. The bottleneck of UA in clinical application is poor water solubility and bioavailability. Until now, many novel UA derivatives have been developed to overtake these problems. In this paper, the relationship between the structure and activity of different functional groups was discussed. All anti-lung cancer ursolic acid derivatives were reviewed, and their biological activity and structure–activity relationship were described. The research progress of UA derivatives against various types of lung cancer was reviewed. |
| Author | Tan, Yan Hu, Yalin Mi, Pengbing Jiang, Kailin Wei, Xueni Lin, Jieying Yao, Xu Song, Li Dai, Ling Hu, Yufei Zheng, Xing |
| Author_xml | – sequence: 1 givenname: Li surname: Song fullname: Song, Li organization: Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China – sequence: 2 givenname: Ling surname: Dai fullname: Dai, Ling organization: Department of Pharmacy, Hunan Vocational College of Science and Technology – sequence: 3 givenname: Yan surname: Tan fullname: Tan, Yan organization: Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China – sequence: 4 givenname: Kailin surname: Jiang fullname: Jiang, Kailin organization: Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China – sequence: 5 givenname: Xueni surname: Wei fullname: Wei, Xueni organization: Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China – sequence: 6 givenname: Yufei surname: Hu fullname: Hu, Yufei organization: Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China – sequence: 7 givenname: Yalin surname: Hu fullname: Hu, Yalin organization: Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China – sequence: 8 givenname: Jieying surname: Lin fullname: Lin, Jieying organization: Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China – sequence: 9 givenname: Xu surname: Yao fullname: Yao, Xu email: 355938360@qq.com organization: Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China – sequence: 10 givenname: Pengbing surname: Mi fullname: Mi, Pengbing email: geyynb@foxmail.com organization: Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China – sequence: 11 givenname: Xing orcidid: 0000-0002-2918-5497 surname: Zheng fullname: Zheng, Xing email: zhengxing9166@sohu.com organization: Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China, Department of Pharmacy, Hunan Vocational College of Science and Technology |
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| Keywords | Ursolic acid derivatives IC Structure–activity relationship Mechanism Anti-lung cancer activities |
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| SubjectTerms | Bioavailability Biochemistry Biological activity Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Drug development Functional groups Inorganic Chemistry Lung cancer Medicinal Chemistry Pharmacology/Toxicology Review Article Toxicity Ursolic acid |
| Title | Advances in research of ursolic acid and its derivatives as potential drug candidates against various types of lung cancers |
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