Recent Progress in the in situ Detrifluoro­acetylative Generation of Fluoro Enolates and Their Reactions with Electrophiles

• Published in: European journal of organic chemistry Vol. 2015; no. 29; pp. 6401 - 6412
• Main Authors: Mei, Haibo, Xie, Chen, Aceña, José Luis, Soloshonok, Vadim A., Röschenthaler, Gerd-Volker, Han, Jianlin
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.09.2015; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Aldol addtion; Asymmetric synthesis; Enolates; Fluorine; Haloform-type reactions; Mannich addition; Michael addition

Detrifluoroacetylative generation of fluoro enolates is an emerging area of high‐impact research. In this review article we provide, for the first time, a comprehensive and critical treatment of this subject. The reaction types reported to date include Mannich, aldol, and Michael addition and haloge...