Aβ1–40 Oligomers Trigger Neutrophil Extracellular Trap Formation through TLR4- and NADPH Oxidase-Dependent Pathways in Age-Related Macular Degeneration

• Published in: Oxidative medicine and cellular longevity Vol. 2022; no. 1; p. 6489923
• Main Authors: Chen, Jinquan, Zhao, Long, Ding, Xuanheng, Wen, Yan, Wang, Lingda, Shu, Qinxin, Xie, Wenxi, Liu, Yanyao, Peng, H.
• Format: Journal Article
• Language: English
• Published: New York Hindawi 01.01.2022; John Wiley & Sons, Inc
• Subjects: Alzheimer's disease; Blood & organ donations; Diabetic retinopathy; Glucose; Human subjects; Inflammation; Macular degeneration; Neutrophils; Pathogens; Peptides; Beijing China; United States > US; China

Neutrophils participate in the advancement of the human innate immune system and respond to perceived endogenous and exogenous threats. As a response mechanism, neutrophil extracellular traps (NETs) form near pathogens and surrounding tissues during an immune response. Drusen is an important marker...