Inhibition of nuclear factor-κB activation improves non-nitric oxide-mediated cutaneous microvascular function in reproductive-aged healthy women

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 327; no. 2; pp. H364 - H369
• Main Authors: Content, Virginia G., Williams, Auni C., Alexander, Lacy M.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.08.2024
• Series: Vascular Biology and Microcirculation
• Subjects: Acetylcholine - pharmacology; Adult; Arginine; Blood pressure; Cardiovascular diseases; Cross-Over Studies; Endothelium; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Enzyme Inhibitors - pharmacology; Female; Health risks; Healthy Volunteers; Humans; Microcirculation - drug effects; Microdialysis; Microvasculature; Microvessels - drug effects; Microvessels - metabolism; NF-kappa B - metabolism; NF-κB protein; NG-Nitroarginine methyl ester; NG-Nitroarginine Methyl Ester - pharmacology; Nitric oxide; Nitric Oxide - metabolism; Placebos; Regional Blood Flow - drug effects; Salicylates - pharmacology; Short Report; Single-Blind Method; Skin - blood supply; Skin - drug effects; Skin - metabolism; Sodium nitroprusside; Transcription activation; Vasodilation - drug effects; Vasodilator Agents - pharmacology; Young Adult; NO-independent vasodilation; NF-κB; microdialysis; inflammation; salsalate

The transcription factor nuclear factor-κB (NF-κB) regulates multiple aspects of innate and adaptive immunity by encoding for genes that participate in inflammation and impact endothelial function following NF-κB inhibition with salsalate treatment. Our results show that cutaneous microvascular func...