A fieldable, high-throughput, cost-efficient high performance liquid chromatography-ultraviolet absorption detection (HPLC-UV) method for the quantitation of bispyridinium quaternary aldoxime cholinesterase reactivators in blood

• Published in: Acta chromatographica Vol. 33; no. 2; pp. 134 - 144
• Main Authors: Karvaly, Gellért Balázs, Tekes, Kornélia, Szimrók, Zoltán, FŰrÉsz, József, KuČa, Kamil, Kalász, Huba
• Format: Journal Article
• Language: English
• Published: Budapest Akademiai Kiado Zrt 01.06.2021
• Subjects: Antidotes; Blood; Cholinesterase; Chromatography; Exposure; High performance liquid chromatography; Ionic strength; Ions; Liquid chromatography; Oximes; Phase separation; Pyridinium; Quantitation; Stationary phase; Ultraviolet absorption

Abstract Mono- and bis-pyridinium quaternary aldoximes (K-oximes) have long been employed as cholinesterase reactivator components of antidotes against lethal cholinesterase-inhibiting organophosphorous chemicals. Their positive charge poses difficulties in their chromatographic analysis, resulting...