NEW SYNTHESIS OF SUBSTITUTED QUINOLINE N-OXIDES VIA CYCLIZATION OF ALKYLIDENE O-NITROARYLACETONITRILES

Substituted quinoline N-oxides are prepared via base induced cyclization of alkylidene derivatives of o-nitroarylacetonitriles which are readily available via the vicarious nucleophilic substitution cyanomethylation of nitroarenes followed by the Knoevenagel condensation.

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 1; pp. 31 - 32
Main Authors WROBEL, Z, KWAST, A, MAKOSZA, M
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.01.1993
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
VICARIOUS NUCLEOPHILIC-SUBSTITUTION
HYDROGEN
NITROARENES
ORGANIC-ANIONS
NITRILES
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Summary:Substituted quinoline N-oxides are prepared via base induced cyclization of alkylidene derivatives of o-nitroarylacetonitriles which are readily available via the vicarious nucleophilic substitution cyanomethylation of nitroarenes followed by the Knoevenagel condensation.
ISSN:0039-7881
DOI:10.1055/s-1993-25781