IL-6 deficiency promotes colitis by recruiting Ly6Chi monocytes into inflamed colon tissues in a CCL2-CCR2-dependent manner

• Published in: European journal of pharmacology Vol. 904; p. 174165
• Main Authors: Cao, Qiuhua, Lin, Yanting, Yue, Chongxiu, Wang, Yue, Quan, Fei, Cui, Xinmeng, Bi, Ran, Tang, Xinying, Yang, Yong, Wang, Chen, Li, Xianjing, Gao, Xinghua
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 05.08.2021
• Subjects: CCL2; Colitis; IL-6; Monocytes; CCL2; Monocytes; Colitis; IL-6

Interleukin 6 (IL-6) is a pleiotropic cytokine that is elevated in inflammatory bowel disease. However, the role of IL-6 deficiency in colitis is not well-defined. Some IL-6 and IL-6 receptor antagonists are associated with severe gastrointestinal immune adverse effects, but the mechanisms of the ef...