Semi-synthesis of novel 1,4-disubstituted-1,2,3-triazole derivatives of penicillin G and their antibacterial activity

• Published in: Phytochemistry letters Vol. 54; pp. 23 - 27
• Main Authors: Rasoolijokari, Kaveh, Salehi, Peyman, Aliahmadi, Atousa, Heidari, Bahareh, Bararjanian, Morteza
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.04.2023
• Subjects: alkynes; Antibacterial; antibacterial properties; azides; bacterial growth; benzylpenicillin; Click chemistry; copper; CuAAC reaction; cycloaddition reactions; Enterococcus faecalis; Escherichia coli; minimum inhibitory concentration; Penicillin G; plant biochemistry; Staphylococcus aureus; Strecker reaction; triazoles; CuAAC reaction; Antibacterial; Click chemistry; Strecker reaction; Penicillin G

A series of 12 novel 1,2,3-triazole penicillin G derivatives were subject to synthesis starting from propargylation of penicillin G followed by copper(I) catalyzed azide alkyne cycloaddition (CuAAC) click reaction. Also, one-pot Strecker reaction was applied aiming for the preparation of 5 novel α-a...