The Effect of Streptozotocin-induced Diabetes on Bone Tissue around Endosseous Implants after Osseointegration

The purpose of this study was to investigate the effects of streptozotocin-induced diabetes on bone tissue around osseointegrated implants. Titanium implants were inserted in the femora of Wistar rats. At 8 weeks after implantation, diabetes was induced by intraperitoneal injection of streptozotocin...

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Bibliographic Details
Published inJapanese Journal of Oral Biology Vol. 44; no. 1; pp. 19 - 28
Main Authors Obata, Toshitake, Oda, Mitsutaka, Kohgo, Takao, Yamamoto, Satoru, Kawasaki, Takao, Yokoyama, Atsuro, Iizuka, Tadashi
Format Journal Article
LanguageEnglish
Published Japanese Association for Oral Biology 2002
Subjects
osseointegration
streptozotocin-induced diabetes
titanium implant
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ISSN0385-0137
DOI10.2330/joralbiosci1965.44.19

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Summary:The purpose of this study was to investigate the effects of streptozotocin-induced diabetes on bone tissue around osseointegrated implants. Titanium implants were inserted in the femora of Wistar rats. At 8 weeks after implantation, diabetes was induced by intraperitoneal injection of streptozotocin (diabetic group). Age-matched rats served as a control group. Rats were sacrificed at 4 weeks after injection of streptozotocin. Histopathological and histomorphometric evaluations were carried out. The amount of newly formed bone in the control group was greater than that of the diabetic group. There was a difference in the ratio of bone-implant contact between the diabetic group and control group.
ISSN:0385-0137
DOI:10.2330/joralbiosci1965.44.19