The Effect of Streptozotocin-induced Diabetes on Bone Tissue around Endosseous Implants after Osseointegration
The purpose of this study was to investigate the effects of streptozotocin-induced diabetes on bone tissue around osseointegrated implants. Titanium implants were inserted in the femora of Wistar rats. At 8 weeks after implantation, diabetes was induced by intraperitoneal injection of streptozotocin...
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| Published in | Japanese Journal of Oral Biology Vol. 44; no. 1; pp. 19 - 28 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japanese Association for Oral Biology
2002
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0385-0137 |
| DOI | 10.2330/joralbiosci1965.44.19 |
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| Abstract | The purpose of this study was to investigate the effects of streptozotocin-induced diabetes on bone tissue around osseointegrated implants. Titanium implants were inserted in the femora of Wistar rats. At 8 weeks after implantation, diabetes was induced by intraperitoneal injection of streptozotocin (diabetic group). Age-matched rats served as a control group. Rats were sacrificed at 4 weeks after injection of streptozotocin. Histopathological and histomorphometric evaluations were carried out. The amount of newly formed bone in the control group was greater than that of the diabetic group. There was a difference in the ratio of bone-implant contact between the diabetic group and control group. |
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| AbstractList | The purpose of this study was to investigate the effects of streptozotocin-induced diabetes on bone tissue around osseointegrated implants. Titanium implants were inserted in the femora of Wistar rats. At 8 weeks after implantation, diabetes was induced by intraperitoneal injection of streptozotocin (diabetic group). Age-matched rats served as a control group. Rats were sacrificed at 4 weeks after injection of streptozotocin. Histopathological and histomorphometric evaluations were carried out. The amount of newly formed bone in the control group was greater than that of the diabetic group. There was a difference in the ratio of bone-implant contact between the diabetic group and control group. |
| Author | Obata, Toshitake Yokoyama, Atsuro Yamamoto, Satoru Kawasaki, Takao Oda, Mitsutaka Iizuka, Tadashi Kohgo, Takao |
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| References | 25) 久米田靖郎, 稲葉雅明: 糖尿病と骨粗鬆症. CLINICAL CALCIUM. (丸茂文昭, 森井浩世, 矢崎義雄編), Vol. 10, pp.1189-1196, 医薬ジャーナル社, 東京, 2000. 15) Fiorellini, J.P., Nevins, M.L., Norkin, A., Weber, H.P. and Karimbux, N.Y.: The effect of insulin therapy on osseointegration in a diabetic rat model. Clin. Oral Impl. Res. 10: 362-368, 1999. 5) Buser, D., Weber, H.P., Bragger, U. and Balsiger, C.: Tissue integration of one-stage ITI implants: 3-year results of a longitudinal study with hollowcylinder and hollow-screw implants. Int. J. Oral Maxillofac. Implants 6: 405-412, 1991. 12) Fiorellini, J.P., Chen, P.K., Nevins, M. and Nevins, M.L.: A retrospective study of dental implants in diabetic patients. Int. J. Periodontics Restorative Dent. 20: 367-373, 2000. 2) Jemt, T., Lekholm, U. and Adell, R.: Osseointegrated implants in the treatment of partially edentulous patients: A preliminary study on 876 consecutively placed fixtures. Int. J. Oral Maxillofac. Implants 4: 211-217, 1989. 11) 木原信市, 須加原一博, 杉田道子: 糖尿病患者の手術と麻酔. 糖尿病 (2). 日本臨床 (1997年増刊号) 55: 626-632, 1997. 8) Albrektsson, T., Branemark, P. -I., Hasson, H.A. and Lundstrom, J.: Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop. Scand. 52: 155-170, 1981 6) Nevins, M. and Langer, B.: The successful application of osseointegrated implants to the posterior jaw: A long-term retrospective study. Int. J. Oral Maxillofac. Implants 8: 428-432, 1993. 3) Buser, D., Weber, H.P. and Bragger, U.: The treatment of partially edentulous patients with ITI hollow-screw implants: Presurgical evaluation and surgical procedures. Int. J. Oral Maxillofac. Implants 5: 165-174, 1990. 10) 大沢英司: 厚生省の糖尿病対策について. 糖尿病 (3). 日本臨床 (1998年増刊号) 56: 819-827, 1998. 14) Iyama, S., Takeshita, F., Ayukawa, Y., Kido, M.A., Suetsugu, T. and Tanaka, T.: A study of regional distribution of bone formed around hydroxyapatite implants in the tibiae of streptozotocin-induced diabetic rats using multiple fluorescent labeling and confocal laser scanning microscopy. J. Periodontol. 68: 1169-1175, 1997. 21) 岩島保法: ケミカル物質による誘発性糖尿病 (ストレプトゾトシン単回投与, 頻回投与). 糖尿病 (3). 日本臨床 (1998年増刊号) 56: 732-737, 1998. 13) Takeshita, F., lyama, S., Ayukawa, Y., Kido, M.A., Murai, K. and Suetsugu, T.: The effects of diabetes on the interface between hydroxyapatite implants and bone in rat tibia. J. Periodontol. 68: 180-185, 1997. 20) Sennerby, L., Thomsen, P. and Ericsson, L.E.: A morphometric and biomechanic comparison of tita-nium implants inserted in rabbit cortical and cancellous bone. Int. J. Oral Maxillofac. Implants 7: 62-71, 1992. 9) Albrektsson, T. and Zarb, G.A.: Current interpretations of the osseointegrated response: Clinical significance. Int. J. Prosthodont. 6: 95-105, 1993. 1) Adell, R., Lekholm, U., Rockler, B. and Branemark, P. -I.: A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int. J. Oral Surg. 10: 387-416, 1981. 22) 尾田充孝: Streptozotocin誘発糖尿病ラットにおける骨代謝に関する病理形態学的研究. 歯基礎誌35: 157-185, 1993. 23) 小林隆: Streptozotocin誘発糖尿病ラットの骨折治癒過程に関する病理形態学的研究. 歯基礎誌32: 600-644, 1990. 4) Branemark, P. -I., Svensson, B. and van Steenberghe, D.: Ten-year survival rates of fixed prostheses on four or six implants ad modum Brinemark in full edentulism. Clin. Oral Impl. Res. 6: 227-231, 1995. 19) Sennerby, L., Odman, J., Lekholm, U. and Thilander, B.: Tissue reactions towards titanium implants inserted in growing jaws. A histological study in the pig. Clin. Oral Impl. Res. 4: 65-75, 1993. 16) Nevins, M.L., Karimbux, N.Y., Weber, H.P., Giannobile, W.V. and Fiorellini, J.P.: Wound healing around endosseous implants in experimental diabetes. Int. J. Oral Maxillofac. Implants 13: 620-629, 1998. 7) Branemark, P. -I.: Introduction to osseointegration. Tissue-integrated prostheses. Osseointegration in clinical dentistry. (edited by Branemark, P. -I., Zarb, G.A. and Albrektsson, T.), pp.11-76, Quintessence Pub. Co., Inc., Chicago, 1985. 18) 松野浩宣, 横山敦郎, 亘理文夫, 宇尾基弘, 川崎貴生: バイオイメージングにより評価したIVa, Va族高融点金属の生体適合性. 歯材器18: 447-462, 1999. 24) 藤田浩, 室田誠逸: 糖尿病と血管内皮細胞障害. 糖尿病 (1). 日本臨床 (1997年増刊号) 55: 738-744, 1997. 17) Olson, J.W., Shernoff, A.F., Tarlow, J.L., Colwell, J.A., Scheetz, J.P. and Bingham, S.F.: Dental endosseous implant assessments in a type 2 diabetic population: A prospective study. Int. J. Oral Maxillofac. Implants 15: 811-818, 2000. |
| References_xml | – reference: 14) Iyama, S., Takeshita, F., Ayukawa, Y., Kido, M.A., Suetsugu, T. and Tanaka, T.: A study of regional distribution of bone formed around hydroxyapatite implants in the tibiae of streptozotocin-induced diabetic rats using multiple fluorescent labeling and confocal laser scanning microscopy. J. Periodontol. 68: 1169-1175, 1997. – reference: 1) Adell, R., Lekholm, U., Rockler, B. and Branemark, P. -I.: A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int. J. Oral Surg. 10: 387-416, 1981. – reference: 19) Sennerby, L., Odman, J., Lekholm, U. and Thilander, B.: Tissue reactions towards titanium implants inserted in growing jaws. A histological study in the pig. Clin. Oral Impl. Res. 4: 65-75, 1993. – reference: 7) Branemark, P. -I.: Introduction to osseointegration. Tissue-integrated prostheses. Osseointegration in clinical dentistry. (edited by Branemark, P. -I., Zarb, G.A. and Albrektsson, T.), pp.11-76, Quintessence Pub. Co., Inc., Chicago, 1985. – reference: 18) 松野浩宣, 横山敦郎, 亘理文夫, 宇尾基弘, 川崎貴生: バイオイメージングにより評価したIVa, Va族高融点金属の生体適合性. 歯材器18: 447-462, 1999. – reference: 20) Sennerby, L., Thomsen, P. and Ericsson, L.E.: A morphometric and biomechanic comparison of tita-nium implants inserted in rabbit cortical and cancellous bone. Int. J. Oral Maxillofac. Implants 7: 62-71, 1992. – reference: 12) Fiorellini, J.P., Chen, P.K., Nevins, M. and Nevins, M.L.: A retrospective study of dental implants in diabetic patients. Int. J. Periodontics Restorative Dent. 20: 367-373, 2000. – reference: 16) Nevins, M.L., Karimbux, N.Y., Weber, H.P., Giannobile, W.V. and Fiorellini, J.P.: Wound healing around endosseous implants in experimental diabetes. Int. J. Oral Maxillofac. Implants 13: 620-629, 1998. – reference: 25) 久米田靖郎, 稲葉雅明: 糖尿病と骨粗鬆症. CLINICAL CALCIUM. (丸茂文昭, 森井浩世, 矢崎義雄編), Vol. 10, pp.1189-1196, 医薬ジャーナル社, 東京, 2000. – reference: 6) Nevins, M. and Langer, B.: The successful application of osseointegrated implants to the posterior jaw: A long-term retrospective study. Int. J. Oral Maxillofac. Implants 8: 428-432, 1993. – reference: 3) Buser, D., Weber, H.P. and Bragger, U.: The treatment of partially edentulous patients with ITI hollow-screw implants: Presurgical evaluation and surgical procedures. Int. J. Oral Maxillofac. Implants 5: 165-174, 1990. – reference: 22) 尾田充孝: Streptozotocin誘発糖尿病ラットにおける骨代謝に関する病理形態学的研究. 歯基礎誌35: 157-185, 1993. – reference: 10) 大沢英司: 厚生省の糖尿病対策について. 糖尿病 (3). 日本臨床 (1998年増刊号) 56: 819-827, 1998. – reference: 11) 木原信市, 須加原一博, 杉田道子: 糖尿病患者の手術と麻酔. 糖尿病 (2). 日本臨床 (1997年増刊号) 55: 626-632, 1997. – reference: 4) Branemark, P. -I., Svensson, B. and van Steenberghe, D.: Ten-year survival rates of fixed prostheses on four or six implants ad modum Brinemark in full edentulism. Clin. Oral Impl. Res. 6: 227-231, 1995. – reference: 2) Jemt, T., Lekholm, U. and Adell, R.: Osseointegrated implants in the treatment of partially edentulous patients: A preliminary study on 876 consecutively placed fixtures. Int. J. Oral Maxillofac. Implants 4: 211-217, 1989. – reference: 21) 岩島保法: ケミカル物質による誘発性糖尿病 (ストレプトゾトシン単回投与, 頻回投与). 糖尿病 (3). 日本臨床 (1998年増刊号) 56: 732-737, 1998. – reference: 23) 小林隆: Streptozotocin誘発糖尿病ラットの骨折治癒過程に関する病理形態学的研究. 歯基礎誌32: 600-644, 1990. – reference: 9) Albrektsson, T. and Zarb, G.A.: Current interpretations of the osseointegrated response: Clinical significance. Int. J. Prosthodont. 6: 95-105, 1993. – reference: 5) Buser, D., Weber, H.P., Bragger, U. and Balsiger, C.: Tissue integration of one-stage ITI implants: 3-year results of a longitudinal study with hollowcylinder and hollow-screw implants. Int. J. Oral Maxillofac. Implants 6: 405-412, 1991. – reference: 24) 藤田浩, 室田誠逸: 糖尿病と血管内皮細胞障害. 糖尿病 (1). 日本臨床 (1997年増刊号) 55: 738-744, 1997. – reference: 8) Albrektsson, T., Branemark, P. -I., Hasson, H.A. and Lundstrom, J.: Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop. Scand. 52: 155-170, 1981 – reference: 17) Olson, J.W., Shernoff, A.F., Tarlow, J.L., Colwell, J.A., Scheetz, J.P. and Bingham, S.F.: Dental endosseous implant assessments in a type 2 diabetic population: A prospective study. Int. J. Oral Maxillofac. Implants 15: 811-818, 2000. – reference: 15) Fiorellini, J.P., Nevins, M.L., Norkin, A., Weber, H.P. and Karimbux, N.Y.: The effect of insulin therapy on osseointegration in a diabetic rat model. Clin. Oral Impl. Res. 10: 362-368, 1999. – reference: 13) Takeshita, F., lyama, S., Ayukawa, Y., Kido, M.A., Murai, K. and Suetsugu, T.: The effects of diabetes on the interface between hydroxyapatite implants and bone in rat tibia. J. Periodontol. 68: 180-185, 1997. |
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| Title | The Effect of Streptozotocin-induced Diabetes on Bone Tissue around Endosseous Implants after Osseointegration |
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