Expedient Synthesis of Ketones via N‐Heterocyclic Carbene/Nickel‐Catalyzed Redox‐Economical Coupling of Alcohols and Alkynes

• Published in: Chinese journal of chemistry Vol. 38; no. 10; pp. 1035 - 1039
• Main Authors: Li, Yu‐Qing, Li, Feng, Shi, Shi‐Liang
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01.10.2020; Wiley Subscription Services, Inc
• Subjects: Additives; Alcohol; Alcohols; Aldehydes; Aliphatic alcohols; Aliphatic compounds; Alkenes; Alkynes; Basic converters; Coupling; Hydrogen transfer; Ketone synthesis; Ketones; Nickel; Nickel catalysis; N‐Heterocyclic carbene ligand

An N‐heterocyclic carbene/Ni‐catalyzed direct coupling of alcohols and internal alkynes for a convenient synthesis of α‐branched ketones is reported. This novel transfer hydrogenation protocol provides an atom‐, and redox‐economical approach to α‐branched ketones, products that are difficult to acce...