Successful treatment of bullous pemphigoid with dupilumab: a case and brief review of the literature

Bullous pemphigoid is an autoimmune skin disease that results in formation of pruritic blisters. Most cases are treated with a combination of systemic and topical corticosteroids as well as other immunomodulatory drugs. Dupilumab is a fully human monoclonal antibody that acts as an antagonist agains...

Full description

Saved in:
Bibliographic Details
Published inDermatology online journal Vol. 27; no. 4
Main Authors Saleh, Maleck, Reedy, Matthew, Torok, Helen, Weaver, Joshua
Format Journal Article
LanguageEnglish
Published United States University of California Digital Library - eScholarship 2021
Subjects
Autoimmune diseases
Dermatology
Eczema
Monoclonal antibodies
Skin diseases
Online AccessGet full text

Cover

Abstract Bullous pemphigoid is an autoimmune skin disease that results in formation of pruritic blisters. Most cases are treated with a combination of systemic and topical corticosteroids as well as other immunomodulatory drugs. Dupilumab is a fully human monoclonal antibody that acts as an antagonist against IL4Ra traditionally used in the treatment of atopic dermatitis. We present an 80-year-old man with moderate to severe bullous pemphigoid successfully treated with dupilumab.
AbstractList Bullous pemphigoid is an autoimmune skin disease that results in formation of pruritic blisters. Most cases are treated with a combination of systemic and topical corticosteroids as well as other immunomodulatory drugs. Dupilumab is a fully human monoclonal antibody that acts as an antagonist against IL4Ra traditionally used in the treatment of atopic dermatitis. We present an 80-year-old man with moderate to severe bullous pemphigoid successfully treated with dupilumab.
Author Weaver, Joshua
Torok, Helen
Saleh, Maleck
Reedy, Matthew
Author_xml – sequence: 1
  givenname: Maleck
  surname: Saleh
  fullname: Saleh, Maleck
– sequence: 2
  givenname: Matthew
  surname: Reedy
  fullname: Reedy, Matthew
  email: mattsreedy@gmail.com
  organization: Northeast Ohio Medical University, Rootstown, OH Trillium Creek Dermatology and Surgery Center, Medina, OH. mattsreedy@gmail.com
– sequence: 3
  givenname: Helen
  surname: Torok
  fullname: Torok, Helen
– sequence: 4
  givenname: Joshua
  surname: Weaver
  fullname: Weaver, Joshua
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33999579$$D View this record in MEDLINE/PubMed
BookMark eNpdkElLBDEQhYMo6qgn7xLwIsholk534k3GFQY8qOcmSVecSG8mHcV_b8QF8VJVh-896r0ZWu-HHhDap-REkIqcXnBWFURwKsQa2qZEVnOW5_qfewvNYnwmhJFC8E20xblSSlRqGzX3yVqI0aUWTwH01EE_4cFhk9p2SBGP0I0r_zT4Br_5aYWbNPo2ddqcYY2tjoB132ATPDgc4NXD26d6WgFu_QRBTynALtpwuo2w97130OPV5cPiZr68u75dnC_nlpVKzJllRtlGS82MNiAFbTQwWjqRc3IjK1fSQhRQOAll6YAJZqgurKKSNYoKvoOOvnzHMLwkiFPd-WihbXUPOUudBVJSLiqa0cN_6POQQp-_yxRXsiJcqEwdf1E2DDEGcPUYfKfDe01J_Vl-_af8TB98eybTQfPL_rTNPwBMgIAp
CitedBy_id crossref_primary_10_3389_fimmu_2021_800609
crossref_primary_10_1080_17512433_2022_2120469
crossref_primary_10_3390_biom13040634
crossref_primary_10_1007_s40278_021_07157_7
crossref_primary_10_1007_s12325_024_02810_3
crossref_primary_10_1016_j_amsu_2021_102799
crossref_primary_10_1111_jdv_17999
crossref_primary_10_1080_07853890_2023_2188487
crossref_primary_10_3389_fimmu_2023_1194088
crossref_primary_10_1155_2024_1171779
crossref_primary_10_3389_fimmu_2022_928621
crossref_primary_10_3390_jcm11123367
crossref_primary_10_1111_jdv_19171
crossref_primary_10_1111_1346_8138_16652
crossref_primary_10_3389_fimmu_2021_738907
crossref_primary_10_1001_jamadermatol_2023_2428
crossref_primary_10_1111_dth_15541
ContentType Journal Article
Copyright 2021. Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the associated terms available at https://creativecommons.org/licenses/by-nc-nd/4.0
Copyright_xml – notice: 2021. Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the associated terms available at https://creativecommons.org/licenses/by-nc-nd/4.0
DBID NPM
AAYXX
CITATION
3V.
7X7
7XB
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
DOI 10.5070/D3274053155
DatabaseName PubMed
CrossRef
ProQuest Central (Corporate)
ProQuest - Health & Medical Complete保健、医学与药学数据库
ProQuest Central (purchase pre-March 2016)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
AUTh Library subscriptions: ProQuest Central
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Access via ProQuest (Open Access)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Central China
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList PubMed
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X7
  name: Health Medical collection
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
EISSN 1087-2108
ExternalDocumentID 10_5070_D3274053155
33999579
Genre Journal Article
GroupedDBID ---
29F
2WC
53G
5GY
5VS
7X7
8FI
8FJ
ABUWG
ADBBV
AFKRA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AUK
BAWUL
BCNDV
BENPR
CCPQU
DIK
EBS
EJD
EMOBN
F5P
FRP
FYUFA
GROUPED_DOAJ
GX1
HMCUK
KQ8
M~E
NPM
OK1
PIMPY
PQQKQ
PROAC
RNS
TR2
UKHRP
W2D
XSB
AAYXX
C1A
CITATION
3V.
7XB
8FK
AZQEC
DWQXO
K9.
PQEST
PQUKI
PRINS
7X8
ID FETCH-LOGICAL-c2695-2c2b9cda8a2babe851dae216f55073b87f61454e4f8e66fe252b1a4c9182d9153
IEDL.DBID 7X7
ISSN 1087-2108
IngestDate Fri Jun 28 17:34:35 EDT 2024
Thu Oct 10 17:53:52 EDT 2024
Fri Aug 23 01:38:48 EDT 2024
Sat Sep 28 08:23:34 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c2695-2c2b9cda8a2babe851dae216f55073b87f61454e4f8e66fe252b1a4c9182d9153
Notes ObjectType-Case Study-3
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-1
ObjectType-Feature-5
ObjectType-Report-2
ObjectType-Article-4
OpenAccessLink https://www.proquest.com/docview/2539870359?pq-origsite=%requestingapplication%
PMID 33999579
PQID 2539870359
PQPubID 4379818
ParticipantIDs proquest_miscellaneous_2528813571
proquest_journals_2539870359
crossref_primary_10_5070_D3274053155
pubmed_primary_33999579
PublicationCentury 2000
PublicationDate 2021-00-00
PublicationDateYYYYMMDD 2021-01-01
PublicationDate_xml – year: 2021
  text: 2021-00-00
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Oakland
PublicationTitle Dermatology online journal
PublicationTitleAlternate Dermatol Online J
PublicationYear 2021
Publisher University of California Digital Library - eScholarship
Publisher_xml – name: University of California Digital Library - eScholarship
SSID ssj0020453
Score 2.3871768
SecondaryResourceType review_article
Snippet Bullous pemphigoid is an autoimmune skin disease that results in formation of pruritic blisters. Most cases are treated with a combination of systemic and...
SourceID proquest
crossref
pubmed
SourceType Aggregation Database
Index Database
SubjectTerms Autoimmune diseases
Dermatology
Eczema
Monoclonal antibodies
Skin diseases
Title Successful treatment of bullous pemphigoid with dupilumab: a case and brief review of the literature
URI https://www.ncbi.nlm.nih.gov/pubmed/33999579
https://www.proquest.com/docview/2539870359
https://search.proquest.com/docview/2528813571
Volume 27
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEF60vXgRxVe0lhV6DU12k23iRXy0FMEiaqG3sJPdlYIk0Tb_39kkTXvRc17w7Wbm-2bnQciAe-BJQJEDIEM3COPUhcDjrgTlpSgnhGdsvfPLTEznwfMiXDQBt1WTVrmxiZWhVnlqY-RDFnKUx7bh3F3x7dqpUfZ0tRmhsU-6PvOETekaLbaCC-kKr2vykPV4wyeOEsxuOlvXt-uF_qCWlYuZHJHDhhvS-3oxj8mezk6Iei-rmYam_KJtVjjNDQUUjyjbaaFxQZaf-VJRG1SlqiyWaHEk3FJJU3RSVGaKAkpiQ-tCFfs08j761bZUPiXzyfjjceo2oxHclIk4dFnKIE6VjCQDCRppk5Ka-cLY9mQcopFBtxsGOjCRFsJoFjLwZZDGKCdUjFbujHSyPNMXhILUBp9WdhBSIISWiCQTwGMu9CiSwiGDDVRJUXfASFA5WESTHUQd0tvAmDS_wSrZLppDbtrLuIHtqYTMNKKE97Ao8nk48h1yXsPffocjfbLniJf_v_yKHDCbalJFRnqks_4p9TVyhTX0qw3RJ92H8ez1rV8p7l_fPMGH
link.rule.ids 315,783,787,867,4031,12068,21400,27935,27936,27937,31731,31732,33756,33757,43322,43817
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1NT8MwDI1gHOCCQHwNBgRp12pt0mYtF4SAacC2C5u0WxU3CZo0dYNt_x-77TYucG7TSnZiv2fHNmNN6YOvAUkOgI68MEoyD0JfehqMnyGdUL6jeuf-QHVH4ds4GlcBt0V1rXJtEwtDbWYZxchbIpJIj6nh3MP8y6OpUZRdrUZo7LI96sNFEwza4y3hQrgiy5o8RD1-61kiBaNNR3V9v73QH9CycDGdI3ZYYUP-WCrzmO3Y_ISZj1Ux09CtpnxzK5zPHAckj0jb-dyiQiafs4nhFFTlZjWfoMXRcM81z9BJcZ0bDkiJHS8LVWg14j4-3bRUPmWjzsvwqetVoxG8TKgk8kQmIMmMjrUADRZhk9FWBMpRezIJcduh241CG7rYKuWsiAQEOswSpBMmQSt3xmr5LLcXjIO2DlcbGoQUKmV1IJCXgUyksu1YqzprrkWVzssOGCkyB5Jo-kuiddZYizGtjsEi3Sqtzu42j3EDU1ZC5xalhO-IOA5k1A7q7LwU_-Y_EuET5REv___4LdvvDvu9tPc6eL9iB4KunRRRkgarLb9X9hpxwxJuis3xA2vZwd8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Successful+treatment+of+bullous+pemphigoid+with+dupilumab%3A+a+case+and+brief+review+of+the+literature&rft.jtitle=Dermatology+online+journal&rft.au=Saleh%2C+Maleck&rft.au=Reedy%2C+Matthew&rft.au=Torok%2C+Helen&rft.au=Weaver%2C+Joshua&rft.date=2021&rft.pub=University+of+California+Digital+Library+-+eScholarship&rft.eissn=1087-2108&rft.volume=27&rft.issue=4&rft_id=info:doi/10.5070%2FD3274053155
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1087-2108&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1087-2108&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1087-2108&client=summon