MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression

• Published in: Clinical science (1979) Vol. 123; no. 3; pp. 161 - 171
• Main Authors: Tabuchi, Tsuyoshi, Satoh, Mamoru, Itoh, Tomonori, Nakamura, Motoyuki
• Format: Journal Article
• Language: English
• Published: England 01.08.2012
• Subjects: Aged; Atorvastatin Calcium; Cell Count; Cell Movement - drug effects; Cells, Cultured; Coronary Artery Disease - blood; Coronary Artery Disease - drug therapy; Coronary Artery Disease - genetics; Endothelial Cells - drug effects; Endothelial Cells - pathology; Female; Fluorobenzenes - pharmacology; Fluorobenzenes - therapeutic use; Gene Expression Regulation - drug effects; Heptanoic Acids - pharmacology; Heptanoic Acids - therapeutic use; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Lipids - blood; Longevity - drug effects; Longevity - genetics; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Oxidative Stress - drug effects; Pyrimidines - pharmacology; Pyrimidines - therapeutic use; Pyrroles - pharmacology; Pyrroles - therapeutic use; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rosuvastatin Calcium; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Sulfonamides - pharmacology; Sulfonamides - therapeutic use; Transfection

Endothelial senescence is thought to play a role in CAD (coronary artery disease). miR-34a (microRNA-34a) and other SIRT1 (silent information regulator 1)-related miRs have recently been found to target SIRT1 leading to endothelial senescence. In the present study, we investigated whether SIRT1-rela...