Exon 5 Polymorphisms in the O 6-Alkylguanine DNA Alkyltransferase Gene and Lung Cancer Risk in Non–Smokers Exposed to Second-Hand Smoke

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 13; no. 2; pp. 320 - 323
• Main Authors: Cohet, Catherine, Borel, Stephane, Nyberg, Fredrik, Mukeria, Anush, Brüske-Hohlfeld, Irene, Constantinescu, Vali, Benhamou, Simone, Brennan, Paul, Hall, Janet, Boffetta, Paolo
• Format: Journal Article
• Language: English
• Published: 01.02.2004

Purpose: The objective of the study was to examine the association of three exon 5 variants in the O6-alkylguanine DNA alkyltransferase (AGT) gene involved in the repair of the mutagenic DNA lesion O6-alkylguanine formed by nitrosamines, with lung cancer risk in never-smokers. Experimental Design: E...