Cingulin-nonmuscle myosin interaction plays a role in epithelial morphogenesis and cingulin nanoscale organization

• Published in: Journal of cell science Vol. 137; no. 18
• Main Authors: Rouaud, Florian, Maupérin, Marine, Mutero-Maeda, Annick, Citi, Sandra
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 15.09.2024
• Subjects: Animals; Dogs; Epithelial Cells - metabolism; Epithelium - growth & development; Epithelium - metabolism; Humans; Madin Darby Canine Kidney Cells; Mice; Morphogenesis; Myosin Heavy Chains - genetics; Myosin Heavy Chains - metabolism; Nonmuscle Myosin Type IIB - genetics; Nonmuscle Myosin Type IIB - metabolism; Protein Binding; Tight Junctions - metabolism; Hearing; Epithelial cells; Cyst morphogenesis; Nonmuscle myosin; Cingulin

Cingulin (CGN) tethers nonmuscle myosin 2B (NM2B; heavy chain encoded by MYH10) to tight junctions (TJs) to modulate junctional and apical cortex mechanics. Here, we studied the role of the CGN-nonmuscle myosin 2 (NM2) interaction in epithelial morphogenesis and nanoscale organization of CGN by expr...