Seroreactivity and immunogenicity of Tp0965, a hypothetical membrane protein of Treponema pallidum

• Published in: Chinese medical journal Vol. 125; no. 11; pp. 1920 - 1924
• Main Authors: Long, Fu-Quan, Zhang, Jin-Ping, Shang, Guang-Dong, Shang, Shu-Xian, Gong, Kuang-Long, Wang, Qian-Qiu
• Format: Journal Article
• Language: English
• Published: China Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042,China%Jiangsu Key Laboratory for Microbes and Functional Genomics,College of Life Sciences, Nanjing Normal University, Nanjing,Jiangsu 210046, China 01.06.2012
• Subjects: Animals; Antigens, Bacterial - genetics; Antigens, Bacterial - immunology; Bacterial Proteins - genetics; Bacterial Proteins - immunology; Enzyme-Linked Immunosorbent Assay; Humans; Membrane Proteins - genetics; Membrane Proteins - immunology; Polymerase Chain Reaction; Rabbits; Syphilis - immunology; Syphilis - microbiology; Treponema pallidum - immunology; Treponema pallidum - metabolism; 免疫原性; 基因组DNA提取; 梅毒螺旋体; 聚合酶链反应; 膜蛋白; 血清学诊断; 重组蛋白; 间接酶联免疫吸附试验; membrane protein; diagnosis; reactivity; recombination; Tp0965; Treponema pallidum

Background Treponema pallidum （T. pallidum） subsp, pallidum is the causative agent of syphilis. Analysis of recombinant antigens of T. pallidum led to the identification of potential candidate antigens for vaccine development and syphilis serodiagnosis. Tp0965 was predicted to be a membrane fusion p...