The Diverse Roles of Spliceosomal Proteins in the Regulation of Cell Processes

• Published in: Russian journal of bioorganic chemistry Vol. 45; no. 1; pp. 1 - 8
• Main Authors: Anufrieva, K. S., Shender, V. O., Arapidi, G. P., Lagarkova, M. A., Govorun, V. M.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2019; Springer Nature B.V
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Deoxyribonucleic acid; DNA; Elongation; Gene expression; Gene sequencing; Genes; Life Sciences; Mutation; Organic Chemistry; Proteins; Review Article; Splicing; spliceosomal proteins; pre-mRNA splicing

The spliceosome is necessary for the removal of intron sequences in transcribed pre-mRNA in eukaryotic cells. More than 200 proteins are involved in the process of pre-mRNA splicing; they coordinate the alternative splicing of most eukaryotic genes, which participate in the regulation of a variety o...