Pd(OAc)2/DABCO as an efficient and phosphine-free catalytic system for the synthesis of single and double Weinreb amides by the aminocarbonylation of aryl iodides

• Published in: Organic & biomolecular chemistry Vol. 12; no. 30; pp. 5727 - 5732
• Main Authors: Gadge, Sandip T, Bhanage, Bhalchandra M
• Format: Journal Article
• Language: English
• Published: England 14.08.2014

This work reports a mild, stable and efficient Pd(OAc)2/DABCO catalysed protocol for the synthesis of single and double Weinreb amides. Double Weinreb amides, having 1,4-phenylene- and biphenylene-linkers - important backbones for the synthesis of biologically active symmetrical resorcylate oligomer...