Donor programmed cell death 1 ligand 1 is required for organ transplant tolerance in major histocompatibility complex-mismatched mixed chimeras although programmed cell death 1 ligand 1 and major histocompatibility complex class II are not required for inducing chimerism

• Published in: American journal of transplantation Vol. 23; no. 8; pp. 1116 - 1129
• Main Authors: Huang, Yaxun, Wu, Xiwei, Tang, Shanshan, Wu, Huiqing, Nasri, Ubaydah, Qin, Qi, Song, Qingxiao, Wang, Bixin, Tao, Hansen, Chong, Anita S., Riggs, Arthur D., Zeng, Defu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2023
• Subjects: MHC II; mixed chimerism; organ transplant tolerance; PD-L1; NRP1; MHC II; LN; pTreg; MNC; mixed chimerism; Treg; MHC; HTX; SPL; DT; PB; organ transplant tolerance; MC; STX; PD-L1; HCT; HLA; COH; PD-1; Tem; WT; tTreg

Induction of major histocompatibility complex (MHC) human leukocyte antigen (HLA)-mismatched mixed chimerism is a promising approach for organ transplantation tolerance; however, human leukocyte antigen-mismatched stable mixed chimerism has not been achieved in the clinic. Tolerogenic dendritic cell...