Inhibition of periostin gene expression via RNA interference suppressed the proliferation, apoptosis and invasion in U2OS cells

• Published in: Chinese medical journal Vol. 123; no. 24; pp. 3677 - 3683
• Main Authors: Liu, Chang, Huang, Si-Jian, Qin, Ze-Lian
• Format: Journal Article
• Language: English
• Published: China Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China 01.12.2010
• Subjects: Apoptosis; Bone Neoplasms - etiology; Bone Neoplasms - pathology; Cell Adhesion Molecules - antagonists & inhibitors; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - physiology; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Focal Adhesion Protein-Tyrosine Kinases - metabolism; Humans; Integrin alphaVbeta3 - physiology; Neoplasm Invasiveness; Osteosarcoma - etiology; Osteosarcoma - pathology; Phosphorylation; RNA Interference; RNA干扰; Transfection; Western印迹; 基因表达; 细胞凋亡; 细胞增殖; 血管内皮生长因子; 逆转录聚合酶链反应; cell function; RNA interference; periostin; U2OS

Background Periostin originally designated osteoblast-specific factor 2 （OSF-2） is frequently found to be highly expressed in various types of human cancer cell lines in vitro and human cancer tissues in vivo. We proposed that periostin was a key factor during the process of proliferation and invasi...