Current practices and challenges in the standardization and harmonization of clinical laboratory tests
Effective patient care, clinical research, and public health efforts require comparability of laboratory results independent of time, place, and measurement procedure. Comparability is achieved by establishing metrological traceability, which ensures that measurement procedures measure the same quan...
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Published in | The American journal of clinical nutrition Vol. 104 Suppl 3; pp. 907S - 912S |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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United States
01.09.2016
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Abstract | Effective patient care, clinical research, and public health efforts require comparability of laboratory results independent of time, place, and measurement procedure. Comparability is achieved by establishing metrological traceability, which ensures that measurement procedures measure the same quantity and that the calibration of measurement procedures is traceable to a common reference system consisting of reference methods and materials. Whereas standardization ensures traceability to the International System of Units, harmonization ensures traceability to a reference system agreed on by convention. This article provides an overview of standardization and harmonization with an emphasis on commutability as an important variable that affects testing accuracy. Commutability of reference materials is required to ensure that traceability is established appropriately and that laboratory results are comparable. The use of noncommutable reference materials leads to inaccurate results. Whereas procedures and protocols for standardizing measurements are established and have been successfully applied in efforts such as the Hormones Standardization Program of the CDC, harmonization activities require new, more complex procedures and approaches. The American Association for Clinical Chemistry, together with its domestic and international partners, formed the International Consortium for Harmonization of Clinical Laboratory Results to coordinate harmonization efforts. Reference systems, as well as procedures and protocols to establish traceability of clinical laboratory tests, have been established and continue to be developed by national and international groups and organizations. Serum tests of thyroid function, including those for the thyroid hormones thyroxine and triiodothyronine, are among the clinical procedures for which standardization efforts are well under way. Approaches to the harmonization of measurement procedures for serum concentrations of thyroid-stimulating hormone are likewise under development. |
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AbstractList | Effective patient care, clinical research, and public health efforts require comparability of laboratory results independent of time, place, and measurement procedure. Comparability is achieved by establishing metrological traceability, which ensures that measurement procedures measure the same quantity and that the calibration of measurement procedures is traceable to a common reference system consisting of reference methods and materials. Whereas standardization ensures traceability to the International System of Units, harmonization ensures traceability to a reference system agreed on by convention. This article provides an overview of standardization and harmonization with an emphasis on commutability as an important variable that affects testing accuracy. Commutability of reference materials is required to ensure that traceability is established appropriately and that laboratory results are comparable. The use of noncommutable reference materials leads to inaccurate results. Whereas procedures and protocols for standardizing measurements are established and have been successfully applied in efforts such as the Hormones Standardization Program of the CDC, harmonization activities require new, more complex procedures and approaches. The American Association for Clinical Chemistry, together with its domestic and international partners, formed the International Consortium for Harmonization of Clinical Laboratory Results to coordinate harmonization efforts. Reference systems, as well as procedures and protocols to establish traceability of clinical laboratory tests, have been established and continue to be developed by national and international groups and organizations. Serum tests of thyroid function, including those for the thyroid hormones thyroxine and triiodothyronine, are among the clinical procedures for which standardization efforts are well under way. Approaches to the harmonization of measurement procedures for serum concentrations of thyroid-stimulating hormone are likewise under development. |
Author | Vesper, Hubert W Miller, W Greg Myers, Gary L |
Author_xml | – sequence: 1 givenname: Hubert W surname: Vesper fullname: Vesper, Hubert W email: hvesper@cdc.gov organization: Division of Laboratory Sciences, National Center for Environmental Health, CDC, Atlanta, GA; hvesper@cdc.gov – sequence: 2 givenname: Gary L surname: Myers fullname: Myers, Gary L organization: American Association for Clinical Chemistry, Washington, DC; and – sequence: 3 givenname: W Greg surname: Miller fullname: Miller, W Greg organization: Virginia Commonwealth University, Richmond, VA |
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Cites_doi | 10.1373/clinchem.2009.140178 10.1373/clinchem.2011.172726 10.1373/clinchem.2009.124743 10.1373/clinchem.2008.118380 10.1373/clinchem.2013.208785 10.1016/j.urology.2013.12.024 10.1016/j.cca.2014.06.009 10.1016/j.cca.2014.01.014 10.1373/clinchem.2008.107052 10.3945/ajcn.115.110379 10.1373/clinchem.2005.059170 10.1210/jc.2006-1864 10.3109/00313025.2010.495246 10.3945/ajcn.115.110361 10.1210/jc.2012-3780 10.1373/clinchem.2011.164012 10.1373/clinchem.2007.101287 10.1258/acb.2011.011079 10.1373/clinchem.2009.124578 10.1016/S0009-8981(98)00042-4 10.1373/clinchem.2013.210302 10.3343/alm.2014.34.3.187 10.4103/1008-682X.122338 10.5858/2005-129-310-ABOTFT 10.1016/j.steroids.2008.08.001 |
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References | Miller (10.3945/ajcn.115.110387_bib3) 2009; 55 Rosner (10.3945/ajcn.115.110387_bib13) 2008; 73 (10.3945/ajcn.115.110387_bib36) 2010 Miller (10.3945/ajcn.115.110387_bib21) 2011; 57 Little (10.3945/ajcn.115.110387_bib27) 2008; 54 Miller (10.3945/ajcn.115.110387_bib6) 2014; 34 Bachmann (10.3945/ajcn.115.110387_bib31) 2014; 60 Sokoll (10.3945/ajcn.115.110387_bib26) 2011; 57 10.3945/ajcn.115.110387_bib10 Vesper (10.3945/ajcn.115.110387_bib33) 2007; 28 Thienpont (10.3945/ajcn.115.110387_bib35) 2010; 56 Faix (10.3945/ajcn.115.110387_bib11) 2016; 104 (10.3945/ajcn.115.110387_bib2) 2003 (10.3945/ajcn.115.110387_bib9) 2014 Sturgeon (10.3945/ajcn.115.110387_bib28) 2009; 55 10.3945/ajcn.115.110387_bib12 10.3945/ajcn.115.110387_bib34 (10.3945/ajcn.115.110387_bib8) 1998; L 331 Paduch (10.3945/ajcn.115.110387_bib16) 2014; 83 White (10.3945/ajcn.115.110387_bib4) 2011; 48 Rose (10.3945/ajcn.115.110387_bib24) 1998; 273 Caliendo (10.3945/ajcn.115.110387_bib29) 2009; 55 Wieringa (10.3945/ajcn.115.110387_bib32) 2014; 432 Long (10.3945/ajcn.115.110387_bib7) 2016; 104 Vesper (10.3945/ajcn.115.110387_bib19) 2014; 16 10.3945/ajcn.115.110387_bib20 Steele (10.3945/ajcn.115.110387_bib1) 2005; 129 Rosner (10.3945/ajcn.115.110387_bib15) 2007; 92 (10.3945/ajcn.115.110387_bib18) 2002 Miller (10.3945/ajcn.115.110387_bib23) 2013; 59 Tate (10.3945/ajcn.115.110387_bib30) 2010; 42 Vesper (10.3945/ajcn.115.110387_bib5) 2009; 55 Rosner (10.3945/ajcn.115.110387_bib14) 2013; 98 Wang (10.3945/ajcn.115.110387_bib17) 2014; 436 Stephan (10.3945/ajcn.115.110387_bib25) 2006; 52 10.3945/ajcn.115.110387_bib22 |
References_xml | – volume: 56 start-page: 902 year: 2010 ident: 10.3945/ajcn.115.110387_bib35 article-title: Report of the IFCC Working Group for Standardization of Thyroid Function Tests; part 1: thyroid-stimulating hormone publication-title: Clin Chem doi: 10.1373/clinchem.2009.140178 contributor: fullname: Thienpont – volume: 57 start-page: 1776 year: 2011 ident: 10.3945/ajcn.115.110387_bib26 article-title: Is the WHO 90:10 prostate-specific antigen (PSA) first international reference standard really 90% α1-antichymotrypsin-bound PSA and 10% free PSA? publication-title: Clin Chem doi: 10.1373/clinchem.2011.172726 contributor: fullname: Sokoll – year: 2010 ident: 10.3945/ajcn.115.110387_bib36 – volume: 55 start-page: 1701 year: 2009 ident: 10.3945/ajcn.115.110387_bib29 article-title: A commutable cytomegalovirus calibrator is required to improve the agreement of viral load values between laboratories publication-title: Clin Chem doi: 10.1373/clinchem.2009.124743 contributor: fullname: Caliendo – ident: 10.3945/ajcn.115.110387_bib34 – volume: 55 start-page: 1011 year: 2009 ident: 10.3945/ajcn.115.110387_bib3 article-title: Toward standardization of insulin immunoassays publication-title: Clin Chem doi: 10.1373/clinchem.2008.118380 contributor: fullname: Miller – volume: 59 start-page: 1291 year: 2013 ident: 10.3945/ajcn.115.110387_bib23 article-title: Commutability still matters publication-title: Clin Chem doi: 10.1373/clinchem.2013.208785 contributor: fullname: Miller – volume: 83 start-page: 980 year: 2014 ident: 10.3945/ajcn.115.110387_bib16 article-title: The laboratory diagnosis of testosterone deficiency publication-title: Urology doi: 10.1016/j.urology.2013.12.024 contributor: fullname: Paduch – volume: 436 start-page: 263 year: 2014 ident: 10.3945/ajcn.115.110387_bib17 article-title: Total testosterone quantitative measurement in serum by LC-MS/MS publication-title: Clin Chim Acta doi: 10.1016/j.cca.2014.06.009 contributor: fullname: Wang – volume: 432 start-page: 68 year: 2014 ident: 10.3945/ajcn.115.110387_bib32 article-title: The harmonisation of growth hormone measurements: taking the next steps publication-title: Clin Chim Acta doi: 10.1016/j.cca.2014.01.014 contributor: fullname: Wieringa – volume: 55 start-page: 1067 year: 2009 ident: 10.3945/ajcn.115.110387_bib5 article-title: Traceability in laboratory medicine publication-title: Clin Chem doi: 10.1373/clinchem.2008.107052 contributor: fullname: Vesper – ident: 10.3945/ajcn.115.110387_bib22 – volume: 104 start-page: 913S year: 2016 ident: 10.3945/ajcn.115.110387_bib11 article-title: Progress in standardizing and harmonizing thyroid function tests publication-title: Am J Clin Nutr doi: 10.3945/ajcn.115.110379 contributor: fullname: Faix – ident: 10.3945/ajcn.115.110387_bib20 – volume: 52 start-page: 59 year: 2006 ident: 10.3945/ajcn.115.110387_bib25 article-title: Interchangeability of measurements of total and free prostate-specific antigen in serum with 5 frequently used assay combinations: an update publication-title: Clin Chem doi: 10.1373/clinchem.2005.059170 contributor: fullname: Stephan – volume: 92 start-page: 405 year: 2007 ident: 10.3945/ajcn.115.110387_bib15 article-title: Position statement: utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-1864 contributor: fullname: Rosner – year: 2003 ident: 10.3945/ajcn.115.110387_bib2 – volume: 42 start-page: 402 year: 2010 ident: 10.3945/ajcn.115.110387_bib30 article-title: Standardisation of cardiac troponin I measurement: past and present publication-title: Pathology doi: 10.3109/00313025.2010.495246 contributor: fullname: Tate – ident: 10.3945/ajcn.115.110387_bib10 – volume: 104 start-page: 902S year: 2016 ident: 10.3945/ajcn.115.110387_bib7 article-title: Development of Standard Reference Materials to support assessment of iodine status for nutritional and public health purposes publication-title: Am J Clin Nutr doi: 10.3945/ajcn.115.110361 contributor: fullname: Long – volume: 98 start-page: 1376 year: 2013 ident: 10.3945/ajcn.115.110387_bib14 article-title: Challenges to the measurement of estradiol: an endocrine society position statement publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-3780 contributor: fullname: Rosner – ident: 10.3945/ajcn.115.110387_bib12 – volume: L 331 start-page: 1 year: 1998 ident: 10.3945/ajcn.115.110387_bib8 article-title: Directive 98/79/EC of the European Parliament and of the Council of 27 October 1998 on in vitro diagnostic medical devices publication-title: Official Journal of the European Communities – volume: 57 start-page: 1108 year: 2011 ident: 10.3945/ajcn.115.110387_bib21 article-title: Roadmap for harmonization of clinical laboratory measurement procedures publication-title: Clin Chem doi: 10.1373/clinchem.2011.164012 contributor: fullname: Miller – volume: 54 start-page: 1023 year: 2008 ident: 10.3945/ajcn.115.110387_bib27 article-title: Standardization of C-peptide measurements publication-title: Clin Chem doi: 10.1373/clinchem.2007.101287 contributor: fullname: Little – volume: 48 start-page: 393 year: 2011 ident: 10.3945/ajcn.115.110387_bib4 article-title: Metrological traceability in clinical biochemistry publication-title: Ann Clin Biochem doi: 10.1258/acb.2011.011079 contributor: fullname: White – volume: 55 start-page: 1484 year: 2009 ident: 10.3945/ajcn.115.110387_bib28 article-title: Differences in recognition of the 1st WHO international reference reagents for hCG-related isoforms by diagnostic immunoassays for human chorionic gonadotropin publication-title: Clin Chem doi: 10.1373/clinchem.2009.124578 contributor: fullname: Sturgeon – volume: 28 start-page: 139 year: 2007 ident: 10.3945/ajcn.115.110387_bib33 article-title: Reference materials and commutability publication-title: Clin Biochem Rev contributor: fullname: Vesper – volume: 273 start-page: 103 year: 1998 ident: 10.3945/ajcn.115.110387_bib24 article-title: Follicle stimulating hormone international standards and reference preparations for the calibration of immunoassays and bioassays publication-title: Clin Chim Acta doi: 10.1016/S0009-8981(98)00042-4 contributor: fullname: Rose – volume: 60 start-page: 471 year: 2014 ident: 10.3945/ajcn.115.110387_bib31 article-title: State of the art for measurement of urine albumin: comparison of routine measurement procedures to isotope dilution tandem mass spectrometry publication-title: Clin Chem doi: 10.1373/clinchem.2013.210302 contributor: fullname: Bachmann – volume: 34 start-page: 187 year: 2014 ident: 10.3945/ajcn.115.110387_bib6 article-title: Harmonization: the sample, the measurement and the report publication-title: Ann Lab Med doi: 10.3343/alm.2014.34.3.187 contributor: fullname: Miller – year: 2014 ident: 10.3945/ajcn.115.110387_bib9 – year: 2002 ident: 10.3945/ajcn.115.110387_bib18 – volume: 16 start-page: 178 year: 2014 ident: 10.3945/ajcn.115.110387_bib19 article-title: Challenges and improvements in testosterone and estradiol testing publication-title: Asian J Androl doi: 10.4103/1008-682X.122338 contributor: fullname: Vesper – volume: 129 start-page: 310 year: 2005 ident: 10.3945/ajcn.115.110387_bib1 article-title: Analytic bias of thyroid function tests: analysis of a College of American Pathologists fresh frozen serum pool by 3900 clinical laboratories publication-title: Arch Pathol Lab Med doi: 10.5858/2005-129-310-ABOTFT contributor: fullname: Steele – volume: 73 start-page: 1285 year: 2008 ident: 10.3945/ajcn.115.110387_bib13 article-title: Preface. CDC workshop report on improving steroid hormone measurements in patient care and research translation publication-title: Steroids doi: 10.1016/j.steroids.2008.08.001 contributor: fullname: Rosner |
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