Triazole-Enabled Ruthenium(II) Carboxylate-Catalyzed C-H Arylation with Electron-Deficient Aryl Halides

• Published in: Synlett Vol. 33; no. 4; pp. 346 - 350
• Main Authors: Rogge, Torben, Mueller, Thomas, Simon, Hendrik, Hou, Xiaoyan, Wagschal, Simon, Broggini, Diego, Ackermann, Lutz
• Format: Journal Article
• Language: English
• Published: STUTTGART Thieme Medical Publishers 02.03.2022
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; PALLADIUM; ACTIVATION; aryl halides; DIVERSIFICATION; ACIDS; C-H bond activation; BOND FUNCTIONALIZATION; CHLORIDES; ruthenium catalysis; hetarenes; arylation; WATER

A triazole-directed direct C-H arylation of arenes with electron-deficient aryl halides or a synthetically useful pyrimidyl chloride was achieved through ruthenium catalysis. Our novel strategy provides operationally simple and environmentally benign access to highly functionalized hetarenes, avoidi...