Long noncoding RNA FEZF1‐AS1 predicts poor prognosis and modulates pancreatic cancer cell proliferation and invasion through miR‐142/HIF‐1α and miR‐133a/EGFR upon hypoxia/normoxia

• Published in: Journal of cellular physiology Vol. 234; no. 9; pp. 15407 - 15419
• Main Authors: Ou, Zheng‐Lin, Zhang, Min, Ji, Lian‐Dong, Luo, Zhen, Han, Tong, Lu, Ye‐Bin, Li, Yi‐Xiong
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2019
• Subjects: Biotechnology; Cancer; Cell growth; Cell proliferation; Epidermal growth factor receptors; FEZF1‐AS1; Hypoxia; invasion; Invasiveness; Kinases; miR‐133a/EGFR; miR‐142/HIF‐1α; Pancreatic cancer; Phenotypes; Ribonucleic acid; RNA; Signal transduction; Tumors; Vascular endothelial growth factor; miR-142/HIF-1α; pancreatic cancer; FEZF1-AS1; invasion; miR-133a/EGFR

Nowadays, pancreatic cancer (PC) remains the most lethal tumor, partially due to the invasive and treatment‐resistant phenotype induced by the extent of hypoxic stress within the tumor tissue. According to previous studies, miR‐142/HIF‐1α and miR‐133a/EGFR could modulate PC cell proliferation under...