Posttreatment monitoring by ASCL1/LHX8 methylation analysis in women with HIV treated for cervical intraepithelial neoplasia grade 2/3

• Published in: AIDS (London) Vol. 36; no. 7; pp. 953 - 961
• Main Authors: Vink, Frederique J, Steenbergen, Renske D M, Kremer, Wieke W, Lissenberg-Witte, Birgit I, Heideman, Daniëlle A M, Bleeker, Maaike C G, van Zummeren, Marjolein, Breytenbach, Erika, Visser, Cathy, Lukhwareni, Azwidowi, Meijer, Chris J L M, Dreyer, Greta
• Format: Journal Article
• Language: English
• Published: England 01.06.2022
• Subjects: Basic Helix-Loop-Helix Transcription Factors - genetics; Cervical Intraepithelial Neoplasia - genetics; Cervical Intraepithelial Neoplasia - pathology; Cervical Intraepithelial Neoplasia - surgery; DNA Methylation; Female; Follow-Up Studies; HIV Infections - complications; Humans; Papillomaviridae - genetics; Papillomavirus Infections - diagnosis; Prospective Studies; Uterine Cervical Neoplasms - diagnosis; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - surgery

Women with HIV (WWH) have an increased risk to develop recurrent cervical intraepithelial neoplasia grade 2/3 (rCIN2/3) after treatment compared with HIV-negative women. Therefore, appropriate posttreatment monitoring of WWH is important. This study evaluates the performance of ASCL1 and LHX8 methyl...