Fibroblast‐derived exosomes promote epithelial cell proliferation through TGF‐β2 signalling pathway in severe asthma

• Published in: Allergy (Copenhagen) Vol. 73; no. 1; pp. 178 - 186
• Main Authors: Haj‐Salem, I., Plante, S., Gounni, A. S., Rouabhia, M., Chakir, J.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.01.2018
• Subjects: Asthma; Cell culture; Cell growth; Cell proliferation; Cell signaling; Chemokines; Culture media; Cytokines; Electron microscopy; Epithelial cells; epithelium proliferation; Exosomes; Fibroblasts; Flow cytometry; Gene expression; Growth factors; Leukocytes (eosinophilic); Respiratory tract; severe asthma; Signal transduction; Sphingomyelin phosphodiesterase; Transfection; transforming growth factor beta 2; Transforming growth factor-b1; severe asthma; transforming growth factor beta 2; fibroblasts; epithelium proliferation; exosomes

Background Bronchial fibroblasts play a key role in airway remodelling in asthma. They regulate epithelial cell functions such as proliferation through growth factors, cytokines, chemokines and exosomes. The role of exosomes in the communication between epithelial cells and fibroblasts by vehiculing...