Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity

• Published in: Human molecular genetics Vol. 21; no. 17; pp. 3845 - 3857
• Main Authors: Vogel, Heike, Scherneck, Stephan, Kanzleiter, Timo, Benz, Verena, Kluge, Reinhart, Stadion, Mandy, Kryvych, Sergiy, Blüher, Matthias, Klöting, Nora, Joost, Hans-Georg, Schürmann, Annette
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.09.2012
• Subjects: 11-beta-Hydroxysteroid Dehydrogenase Type 1 - genetics; 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism; 5' Flanking Region - genetics; Adipose Tissue, White - metabolism; Adipose Tissue, White - pathology; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Biological and medical sciences; Body Weight - genetics; Chromosome Deletion; Chromosomes, Human, Pair 1 - genetics; Exons - genetics; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling; Gene Expression Regulation; Genetics of eukaryotes. Biological and molecular evolution; Humans; Intracellular Signaling Peptides and Proteins - genetics; Medical sciences; Metabolic diseases; Mice; Mice, Inbred C57BL; Mice, Obese; Middle Aged; Molecular and cellular biology; Multigene Family - genetics; Obesity; Obesity - enzymology; Obesity - genetics; Quantitative Trait Loci - genetics; Recombination, Genetic - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; Young Adult; Chromosomal aberration; Obesity; Enzyme; Rodentia; Nutrition disorder; Chromosome 1; Vertebrata; Mammalia; Mouse; Animal; 11β-Hydroxysteroid dehydrogenase; Deletion; Development; Genetics; Oxidoreductases; Nutritional status

Nob3 is a major obesity quantitative trait locus (QTL) identified in an intercross of New Zealand Obese (NZO) mice with C57BL/6J (B6), and by introgression of its 38 Mbp peak region into B6 (B6.NZO-Nob3.38). B6.NZO-Nob3.38 mice carrying the NZO allele exhibited markedly increased body weight, fat ma...