The PNPLA3 rs738409 C>G variant influences the association between low skeletal muscle mass and NAFLD: the Shanghai Changfeng Study

• Published in: Alimentary pharmacology & therapeutics Vol. 50; no. 6; pp. 684 - 695
• Main Authors: Xia, Ming‐Feng, Chen, Ling‐Yan, Wu, Li, Ma, Hui, Li, Qian, Aleteng, Qiqige, Hu, Yu, He, Wan‐Yuan, Gao, Jian, Lin, Huan‐Dong, Gao, Xin
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2019
• Subjects: Adult; Aged; Asian Continental Ancestry Group - genetics; Body fat; Body weight; China; Cigarette smoking; Diabetes mellitus; Fatty liver; Female; Fibrosis; Gene polymorphism; Humans; Lipase - genetics; Liver; Liver diseases; Male; Membrane Proteins - genetics; Metabolic syndrome; Middle Aged; Musculoskeletal system; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - genetics; Obesity; Phospholipase; Polymorphism, Genetic; Sarcopenia; Sarcopenia - complications; Sarcopenia - genetics; Skeletal muscle; Steatosis; Ultrasound; China

Summary Background Age‐related skeletal muscle loss and patatin‐like phospholipase domain‐containing 3 (PNPLA3) polymorphisms are both associated with increased liver steatosis and fibrosis in the absence of obesity. Aim To investigate the influence of PNPLA3 polymorphism on the relationship between...