Regulation of podocyte surface proteins by the enzyme A Disintegrin And Metalloproteinase 10 (ADAM10)

• Published in: Kidney international Vol. 108; no. 2; pp. 214 - 232
• Main Authors: Rosenbaum, David, Reichelt, Julia, Gudaitis, Simonas, Kühne, Stine, Zielinski, Stephanie, Loreth, Desiree, Blume, Lukas, Brand, Johannes, Vitzthum, Helga, Sachs, Wiebke, Lampert, Alina, Seipold, Lisa, Voss, Matthias, Meyer-Schwesinger, Catherine, Saftig, Paul
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2025
• Subjects: ADAM10; ADAM10 Protein - deficiency; ADAM10 Protein - genetics; ADAM10 Protein - metabolism; Amyloid Precursor Protein Secretases - deficiency; Amyloid Precursor Protein Secretases - genetics; Amyloid Precursor Protein Secretases - metabolism; Animals; dystroglycan; ectodomain shedding; Glomerulonephritis, Membranous - enzymology; Glomerulonephritis, Membranous - genetics; Glomerulonephritis, Membranous - pathology; Humans; Membrane Proteins - deficiency; Membrane Proteins - genetics; Membrane Proteins - metabolism; membranous nephropathy antigens; Mice; Mice, Knockout; PLA2R1; Podocytes - enzymology; Podocytes - metabolism; Podocytes - pathology; Proteolysis; Receptors, Phospholipase A2 - metabolism; Swine; THSD7A; ADAM10; ectodomain shedding; dystroglycan; THSD7A; PLA2R1; membranous nephropathy antigens

Podocytes are terminally differentiated cells of the kidney filtration barrier. Their network of interdigitating foot processes embraces the glomerular capillaries and is likely remodeled by cleavage of podocyte surface proteins. The metalloproteinase ADAM10 is a major regulator of such surface prot...