Biogenic Polyamines Influence the Antibiotic Susceptibility and Cell-Surface Properties of Mycobacterium smegmatis

Biogenic polyamines affect the properties of surface of Mycobacterium smegmatis cells. The presence of spermidine and spermine in the culture medium had a significant effect on the cell-surface charge and sliding motility of mycobacteria but did not affect the cell-surface hydrophobicity. Cell aggre...

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Published inApplied biochemistry and microbiology Vol. 56; no. 4; pp. 387 - 394
Main Authors Nesterova, L. Yu, Tsyganov, I. V., Tkachenko, A. G.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2020
Springer Nature B.V
Subjects
Antibiotics
Biochemistry
Biofilms
Biomedical and Life Sciences
Cell aggregation
Cell culture
Cell surface
Hydrophobicity
Life Sciences
Medical Microbiology
Microbiology
Mycobacterium smegmatis
Polyamines
Rifampin
Spermidine
Spermine
Surface charge
Surface properties
sliding
biogenic polyamines
biofilm formation
antibiotic susceptibility
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Summary:Biogenic polyamines affect the properties of surface of Mycobacterium smegmatis cells. The presence of spermidine and spermine in the culture medium had a significant effect on the cell-surface charge and sliding motility of mycobacteria but did not affect the cell-surface hydrophobicity. Cell aggregation in M. smegmatis and the capacity for biofilm formation increased under polyamine treatment. Polyamines also decreased the antibiotic susceptibility of both planktonic forms and biofilms. For the first time, spermine has been shown to enhance the antimycobacterial activity of rifampicin, which is of interest for the treatment of mycobacterial infections.
ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683820040110