O-protected N-(2-nitrophenylsulfonyl)hydroxylamines: Novel reagents for the synthesis of hydroxamates

Preparative methods for novel O-protected N-(2-nitrophenylsulfonyl)hydroxylamines (8a-e) are described. Their versatility as intermediates en route to polyhydroxamates is exemplified by the synthesis of a non-amide DFO analog 22.

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Published inSynthesis (Stuttgart) no. 7; pp. 1086 - 1092
Main Authors Reddy, PA, Schall, OF, Wheatley, Rosik, LO, McClurg, JP, Marshall, GR, Slomczynska, U
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.06.2001
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PEPTIDES
ACIDS
nosyl protecting group
Mitsunobu reaction
ESTERS
SOLID-PHASE
alkylation
N-ALKYLATION
INHIBITORS
hydroxamate
solid-phase synthesis
SECONDARY-AMINES
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Abstract Preparative methods for novel O-protected N-(2-nitrophenylsulfonyl)hydroxylamines (8a-e) are described. Their versatility as intermediates en route to polyhydroxamates is exemplified by the synthesis of a non-amide DFO analog 22.
AbstractList Preparative methods for novel O-protected N-(2-nitrophenylsulfonyl)hydroxylamines (8a-e) are described. Their versatility as intermediates en route to polyhydroxamates is exemplified by the synthesis of a non-amide DFO analog 22.
Author Rosik, LO
Reddy, PA
Slomczynska, U
Schall, OF
Wheatley
Marshall, GR
McClurg, JP
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Issue 7
Keywords PEPTIDES
ACIDS
nosyl protecting group
Mitsunobu reaction
ESTERS
SOLID-PHASE
alkylation
N-ALKYLATION
INHIBITORS
hydroxamate
solid-phase synthesis
SECONDARY-AMINES
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Snippet Preparative methods for novel O-protected N-(2-nitrophenylsulfonyl)hydroxylamines (8a-e) are described. Their versatility as intermediates en route to...
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Physical Sciences
Science & Technology
Title O-protected N-(2-nitrophenylsulfonyl)hydroxylamines: Novel reagents for the synthesis of hydroxamates
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