Prosthetic Aortic Valve Obstruction With Pannus Formation, an Approach for Diagnosis and Management: A Case Report

Mechanical valve obstructions are critical medical and surgical emergencies that require immediate attention when patients present with new complaints and exhibit signs such as the onset of murmurs or the disappearance of mechanical valve clicks. Obstructions can arise from various causes, including...

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Published inCurēus (Palo Alto, CA) Vol. 15; no. 6; p. e40416
Main Authors Mousa, Aliaa, Arshad, Hassaan, Kakhktsyan, Tigran, Rashid, Muhammad Humayoun, Patel, Jigar, Desai, Harit
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 14.06.2023
Cureus
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Abstract Mechanical valve obstructions are critical medical and surgical emergencies that require immediate attention when patients present with new complaints and exhibit signs such as the onset of murmurs or the disappearance of mechanical valve clicks. Obstructions can arise from various causes, including pannus formation, thrombus, vegetations, or subvalvular tissue growth. While pannus formations have been previously reported for the mitral valve, they are less commonly observed in the aortic valve, and several hypotheses have been proposed to understand pannus formation. Accurate diagnosis relies on imaging techniques such as echocardiography and fluoroscopy, and surgical intervention is considered the optimal treatment approach. Here, we present the case of a 69-year-old female who had previously undergone aortic valve replacement and subsequently developed progressive dyspnea, fatigue, and a new onset murmur. Imaging modalities revealed a closed leaflet and a high transvalvular gradient over the valve. The patient underwent a prosthetic redo valve replacement, and post-surgery, she was discharged home without complications.
AbstractList Mechanical valve obstructions are critical medical and surgical emergencies that require immediate attention when patients present with new complaints and exhibit signs such as the onset of murmurs or the disappearance of mechanical valve clicks. Obstructions can arise from various causes, including pannus formation, thrombus, vegetations, or subvalvular tissue growth. While pannus formations have been previously reported for the mitral valve, they are less commonly observed in the aortic valve, and several hypotheses have been proposed to understand pannus formation. Accurate diagnosis relies on imaging techniques such as echocardiography and fluoroscopy, and surgical intervention is considered the optimal treatment approach. Here, we present the case of a 69-year-old female who had previously undergone aortic valve replacement and subsequently developed progressive dyspnea, fatigue, and a new onset murmur. Imaging modalities revealed a closed leaflet and a high transvalvular gradient over the valve. The patient underwent a prosthetic redo valve replacement, and post-surgery, she was discharged home without complications.
Author Patel, Jigar
Arshad, Hassaan
Kakhktsyan, Tigran
Mousa, Aliaa
Desai, Harit
Rashid, Muhammad Humayoun
AuthorAffiliation 3 Cardiovascular Medicine, Capital Health Regional Medical Center, Trenton, USA
2 Internal Medicine, Nishtar Medical University, Multan, PAK
1 Internal Medicine, Capital Health Regional Medical Center, Trenton, USA
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Cites_doi 10.32596/ejcm.galenos.2022.2022-09-046
10.1016/0735-1097(95)00018-Y
10.1016/S0022-5223(03)00702-5
10.1016/j.athoracsur.2013.07.019
10.1007/s12574-010-0064-7
10.1186/s40981-020-0313-3
10.7759/cureus.27198
10.4103/0975-2870.206577
10.1016/0735-1097(92)90389-5
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Issue 6
Keywords fibro collagenous material
fluroscopy
prosthetic valve pannus
aortic valve surgery
mechanical thromb
Language English
License Copyright © 2023, Mousa et al.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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References Ellensen VS (ref4) 2013; 96
Ardehali A (ref3) 1995; 25
Inamdar A (ref9) 2017; 10
Teshima H (ref7) 2003; 126
Asil S (ref10) 2022; 10
Renzulli A (ref5) 1997; 6
Schwartz RS (ref8) 1992; 20
Muro T (ref1) 2011; 9
Panchal A (ref2) 2022; 14
Miyata K (ref6) 2020; 6
References_xml – volume: 10
  year: 2022
  ident: ref10
  article-title: Stuck leaflets in prosthetic heart valves with different etiology and treatments
  publication-title: E J Cardiovasc Med
  doi: 10.32596/ejcm.galenos.2022.2022-09-046
  contributor:
    fullname: Asil S
– volume: 25
  year: 1995
  ident: ref3
  article-title: Coronary blood flow reserve in acute aortic regurgitation
  publication-title: J Am Coll Cardiol
  doi: 10.1016/0735-1097(95)00018-Y
  contributor:
    fullname: Ardehali A
– volume: 126
  year: 2003
  ident: ref7
  article-title: Obstruction of st jude medical valves in the aortic position: histology and immunohistochemistry of pannus
  publication-title: J Thorac Cardiovasc Surg
  doi: 10.1016/S0022-5223(03)00702-5
  contributor:
    fullname: Teshima H
– volume: 96
  year: 2013
  ident: ref4
  article-title: Acute obstruction by pannus in patients with aortic medtronic-hall valves: 30 years of experience
  publication-title: Ann Thorac Surg
  doi: 10.1016/j.athoracsur.2013.07.019
  contributor:
    fullname: Ellensen VS
– volume: 9
  year: 2011
  ident: ref1
  article-title: Intermittent chest pain with marked ST depression after 13 years of aortic valve replacement
  publication-title: J Echocardiogr
  doi: 10.1007/s12574-010-0064-7
  contributor:
    fullname: Muro T
– volume: 6
  year: 2020
  ident: ref6
  article-title: Intraoperative detection of stuck leaflet after implantation of a mechanical aortic valve: a case report
  publication-title: JA Clin Rep
  doi: 10.1186/s40981-020-0313-3
  contributor:
    fullname: Miyata K
– volume: 14
  year: 2022
  ident: ref2
  article-title: Acute severe aortic regurgitation from catastrophic pannus obstruction in a patient with mechanical aortic valve replacement
  publication-title: Cureus
  doi: 10.7759/cureus.27198
  contributor:
    fullname: Panchal A
– volume: 10
  year: 2017
  ident: ref9
  article-title: Prosthetic valve obstruction: redo surgery or fibrinolysis?
  publication-title: Med J Dr. D.Y. Patil University
  doi: 10.4103/0975-2870.206577
  contributor:
    fullname: Inamdar A
– volume: 6
  year: 1997
  ident: ref5
  article-title: Thrombolysis for prosthetic valve thrombosis: indications and results
  publication-title: J Heart Valve Dis
  contributor:
    fullname: Renzulli A
– volume: 20
  year: 1992
  ident: ref8
  article-title: The restenosis paradigm revisited: an alternative proposal for cellular mechanisms
  publication-title: J Am Coll Cardiol
  doi: 10.1016/0735-1097(92)90389-5
  contributor:
    fullname: Schwartz RS
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SubjectTerms Anticoagulants
Auscultation
Blood clots
Cardiac/Thoracic/Vascular Surgery
Cardiology
Case reports
Extracellular matrix
Growth factors
Heart
Hyperplasia
Medical diagnosis
Pathology
Patients
Prostheses
Thrombosis
Ultrasonic imaging
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Title Prosthetic Aortic Valve Obstruction With Pannus Formation, an Approach for Diagnosis and Management: A Case Report
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