Developmental and sex differences in cardiac tolerance to ischemia–reperfusion injury: the role of mitochondria

• Published in: Canadian journal of physiology and pharmacology Vol. 97; no. 9; pp. 808 - 814
• Main Authors: Ostadal, B., Drahota, Z., Houstek, J., Milerova, M., Ostadalova, I., Hlavackova, M., Kolar, F.
• Format: Journal Article
• Language: English
• Published: Ottawa Canadian Science Publishing NRC Research Press 01.09.2019
• Subjects: Age; ATP; ATP synthase; Calcium; Gender differences; Heart; Ischemia; Membrane permeability; Mitochondria; Mitochondrial permeability transition pore; Myocardium; Neonates; Newborn babies; Pharmacology; Physiology; Reperfusion; Sensitivity; Sex differences

Age and sex play an essential role in the cardiac tolerance to ischemia–reperfusion injury: cardiac resistance significantly decreases during postnatal maturation and the female heart is more tolerant than the male myocardium. It is widely accepted that mitochondrial dysfunction, and particularly mi...