Pulmonary Alveolar Microlithiasis in a Middle-Aged Man Presenting With Respiratory Failure: A Case Report and Review of the Literature

Pulmonary alveolar microlithiasis (PAM) is an autosomal recessive disease of the lung, characterized by diffuse deposits of intra-alveolar calcium phosphate microliths. It usually affects both sexes, presenting mostly in the second and third decades. The clinical course is highly variable, ranging f...

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Published inCurēus (Palo Alto, CA) Vol. 16; no. 2; p. e54942
Main Authors Omo-Ogboi, Allen C, Ederhion, Joyce, Ur Rehman, Asad, Ogunleye, Olanrewaju, Thomas-Ogunniyi, Jaiyeola
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 26.02.2024
Cureus
Subjects
Asymptomatic
Calcification
Case reports
Families & family life
Family medical history
Lung diseases
Lungs
Middle age
Mutation
Pathology
Pulmonology
Radiology
Respiratory failure
Transplants & implants
United States > US
pulmonary alveolar microlithiasis
type ii alveolar pneumocytes
bilateral orthotropic lung transplant
intra-alveolar calcium phosphate microliths
slc34a2
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Summary:Pulmonary alveolar microlithiasis (PAM) is an autosomal recessive disease of the lung, characterized by diffuse deposits of intra-alveolar calcium phosphate microliths. It usually affects both sexes, presenting mostly in the second and third decades. The clinical course is highly variable, ranging from being asymptomatic to respiratory failure. PAM is usually diagnosed after careful clinical, radiological, and pathological evaluation, usually when patients present for other medical purposes. Here, a case of PAM in a middle-aged man presenting with acute-on-chronic hypoxemic respiratory failure is reported, with a review of the literature.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.54942