Effectiveness of Upadacitinib for Patients With Acute Severe Ulcerative Colitis: A Multicenter Experience
A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy. Patients with ASUC treated with upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency of stero...
Saved in:
| Published in | The American journal of gastroenterology Vol. 119; no. 7; pp. 1421 - 1425 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
01.07.2024
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy.
Patients with ASUC treated with upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency of steroid-free clinical remission, adverse events, and all-cause readmissions.
Of the 25 patients with ASUC treated with upadacitinib, 6 (24%) patients underwent colectomy, 15 (83%) of the 18 patients with available data and who did not undergo colectomy experienced steroid-free clinical remission (1 patient did not have complete data), 1 (4%) patient experienced a venous thromboembolic event, while 5 (20%) patients were readmitted.
Upadacitinib along with intravenous corticosteroids may be an effective treatment for ASUC. |
|---|---|
| AbstractList | INTRODUCTION:A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy.METHODS:Patients with ASUC treated with upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency of steroid-free clinical remission, adverse events, and all-cause readmissions.RESULTS:Of the 25 patients with ASUC treated with upadacitinib, 6 (24%) patients underwent colectomy, 15 (83%) of the 18 patients with available data and who did not undergo colectomy experienced steroid-free clinical remission (1 patient did not have complete data), 1 (4%) patient experienced a venous thromboembolic event, while 5 (20%) patients were readmitted.DISCUSSION:Upadacitinib along with intravenous corticosteroids may be an effective treatment for ASUC. A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy. Patients with ASUC treated with upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency of steroid-free clinical remission, adverse events, and all-cause readmissions. Of the 25 patients with ASUC treated with upadacitinib, 6 (24%) patients underwent colectomy, 15 (83%) of the 18 patients with available data and who did not undergo colectomy experienced steroid-free clinical remission (1 patient did not have complete data), 1 (4%) patient experienced a venous thromboembolic event, while 5 (20%) patients were readmitted. Upadacitinib along with intravenous corticosteroids may be an effective treatment for ASUC. A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy.INTRODUCTIONA significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy.Patients with ASUC treated with upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency of steroid-free clinical remission, adverse events, and all-cause readmissions.METHODSPatients with ASUC treated with upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency of steroid-free clinical remission, adverse events, and all-cause readmissions.Of the 25 patients with ASUC treated with upadacitinib, 6 (24%) patients underwent colectomy, 15 (83%) of the 18 patients with available data and who did not undergo colectomy experienced steroid-free clinical remission (1 patient did not have complete data), 1 (4%) patient experienced a venous thromboembolic event, while 5 (20%) patients were readmitted.RESULTSOf the 25 patients with ASUC treated with upadacitinib, 6 (24%) patients underwent colectomy, 15 (83%) of the 18 patients with available data and who did not undergo colectomy experienced steroid-free clinical remission (1 patient did not have complete data), 1 (4%) patient experienced a venous thromboembolic event, while 5 (20%) patients were readmitted.Upadacitinib along with intravenous corticosteroids may be an effective treatment for ASUC.DISCUSSIONUpadacitinib along with intravenous corticosteroids may be an effective treatment for ASUC. |
| Author | Barrett, Terrence A Click, Ben Sheehan, Jessica Steiner, Calen A Cohen-Mekelburg, Shirley Ungaro, Ryan C Karl, Taylor Dolinger, Michael Regal, Randolph E Stidham, Ryan W Berinstein, Elliot M Bishu, Shrinivas Patel, Anish Hassan, Syed Adeel Higgins, Peter D R Flomenhoft, Deborah Colombel, Jean-Frederic Levine, Jake Perry, Courtney Berinstein, Jeffrey A Ahmed, Waseem Dulaney, David |
| Author_xml | – sequence: 1 givenname: Jeffrey A orcidid: 0000-0001-7631-9665 surname: Berinstein fullname: Berinstein, Jeffrey A organization: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA – sequence: 2 givenname: Taylor surname: Karl fullname: Karl, Taylor organization: Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA – sequence: 3 givenname: Anish orcidid: 0000-0002-1880-7991 surname: Patel fullname: Patel, Anish organization: Division of Gastroenterology & Hepatology, Brooke Army Medical Center, USA – sequence: 4 givenname: Michael orcidid: 0000-0002-9023-4948 surname: Dolinger fullname: Dolinger, Michael organization: Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA – sequence: 5 givenname: Terrence A orcidid: 0000-0001-6428-3271 surname: Barrett fullname: Barrett, Terrence A organization: Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, Kentucky, USA – sequence: 6 givenname: Waseem orcidid: 0000-0002-5587-7964 surname: Ahmed fullname: Ahmed, Waseem organization: Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA – sequence: 7 givenname: Ben surname: Click fullname: Click, Ben organization: Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA – sequence: 8 givenname: Calen A orcidid: 0000-0002-1964-010 surname: Steiner fullname: Steiner, Calen A organization: Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA – sequence: 9 givenname: David orcidid: 0000-0001-9796-9982 surname: Dulaney fullname: Dulaney, David organization: Division of Gastroenterology & Hepatology, Brooke Army Medical Center, USA – sequence: 10 givenname: Jake surname: Levine fullname: Levine, Jake organization: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA – sequence: 11 givenname: Syed Adeel surname: Hassan fullname: Hassan, Syed Adeel organization: Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, Kentucky, USA – sequence: 12 givenname: Courtney orcidid: 0000-0001-6177-3128 surname: Perry fullname: Perry, Courtney organization: Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, Kentucky, USA – sequence: 13 givenname: Deborah orcidid: 0009-0009-7865-6599 surname: Flomenhoft fullname: Flomenhoft, Deborah organization: Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, Kentucky, USA – sequence: 14 givenname: Ryan C surname: Ungaro fullname: Ungaro, Ryan C organization: Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA – sequence: 15 givenname: Elliot M surname: Berinstein fullname: Berinstein, Elliot M organization: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA – sequence: 16 givenname: Jessica orcidid: 0000-0003-4901-6575 surname: Sheehan fullname: Sheehan, Jessica organization: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA – sequence: 17 givenname: Shirley orcidid: 0000-0001-5058-5527 surname: Cohen-Mekelburg fullname: Cohen-Mekelburg, Shirley organization: VA Center for Clinical Management Research, VA Ann Arbor Health Care System, Ann Arbor, Michigan, USA – sequence: 18 givenname: Randolph E surname: Regal fullname: Regal, Randolph E organization: Department of Pharmacy Services, Michigan Medicine, Ann Arbor, Michigan, USA – sequence: 19 givenname: Ryan W surname: Stidham fullname: Stidham, Ryan W organization: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA – sequence: 20 givenname: Shrinivas orcidid: 0000-0003-4823-5805 surname: Bishu fullname: Bishu, Shrinivas organization: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA – sequence: 21 givenname: Jean-Frederic orcidid: 0000-0001-6472-249 surname: Colombel fullname: Colombel, Jean-Frederic organization: Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA – sequence: 22 givenname: Peter D R orcidid: 0000-0003-1602-4341 surname: Higgins fullname: Higgins, Peter D R organization: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38275248$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkV1LwzAUhoNM3If-BCXgjTedadIujXdjzA-YKOjwsqTpiWZ0bU3Sof_ezE0Rz80Lh_c5nHPeIerVTQ0IncZkHCeMiEu5eh2TP0UnPDlAgzjlNCI0iXtosO1GgnLSR0PnVoTEKeXpEeqzLChNsgEyc61BebOBGpzDjcbLVpZSGW9qU2DdWPwovYHaO_xi_Bueqs4DfoINWMDLSoGVWxrPmiow7gpP8X1XeaMCAhbPP1qwAVdwjA61rByc7HWEltfz59lttHi4uZtNF5EKF_iwrtApgYSyQjBJ45KICc9EJoAJrmTKmSBQABW0UJNEM11mWZmUBWNQUKo4G6GL3dzWNu8dOJ-vjVNQVbKGpnN5IFPCKItJsJ7_s66aztZhu5wRnhLCBcuCK925lG2cs6Dz1pq1tJ95TPLvLPKQRf4_i8Cd7ad3xRrKX-rn-ewLmLmGJA |
| CitedBy_id | crossref_primary_10_1007_s12328_024_01976_1 |
| Cites_doi | 10.1016/j.cgh.2021.05.038 10.1136/gutjnl-2021-326390 10.1016/S2468-1253(16)30003-6 10.1016/j.cgh.2006.09.033 10.1208/s12248-019-0378-y 10.1053/j.gastro.2005.03.003 10.1016/j.cgh.2018.11.022 10.1056/NEJM199406303302601 10.1097/MOG.0000000000000953 10.1093/ecco-jcc/jjad036 10.1016/S0140-6736(12)61084-8 10.1007/s10620-019-05957-0 10.1016/S0140-6736(22)00581-5 10.1016/j.cgh.2022.11.029 10.1016/S0140-6736(74)90552-2 |
| ContentType | Journal Article |
| Copyright | Copyright © 2024 by The American College of Gastroenterology. 2024 by The American College of Gastroenterology |
| Copyright_xml | – notice: Copyright © 2024 by The American College of Gastroenterology. – notice: 2024 by The American College of Gastroenterology |
| DBID | NPM AAYXX CITATION K9. 7X8 |
| DOI | 10.14309/ajg.0000000000002674 |
| DatabaseName | PubMed CrossRef ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | PubMed CrossRef ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitleList | ProQuest Health & Medical Complete (Alumni) PubMed MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1572-0241 |
| EndPage | 1425 |
| ExternalDocumentID | 10_14309_ajg_0000000000002674 38275248 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: K23 DK134764 – fundername: NIDDK NIH HHS grantid: R01 DK124779 – fundername: NIDDK NIH HHS grantid: DK134764 |
| GroupedDBID | --- 0R~ 123 23M 36B 39C 4.4 5RE 6J9 70F 8GM AAAAV AAGIX AAHPQ AAIQE AAJCS AAMOA AAQKA AASCR AASXQ ABASU ABDIG ABJNI ABLJU ABOCM ABVCZ ACGFO ACGFS ACILI ACKTT ACLDA ACNWC ACOAL ACXJB ADBBV ADFRT ADGGA ADHPY AEBDS AENEX AEXYK AFDTB AFEBI AFEXH AFUWQ AGAYW AHMBA AHOMT AHQNM AHSBF AINUH AJIOK AJNWD AJRNO AJZMW AKRWK AKULP ALIPV ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW BENPR BYPQX C45 CS3 DIWNM EBS EE. EEVPB EJD EMB ERAAH F5P FCALG FDB FDQFY GNXGY GQDEL HLJTE HZ~ IHE IKREB IKYAY IPNFZ JSO NPM O9- ODMTH OPUJH OVD OVDNE P0W P2P RIG RLZ RNT RNTTT SEW SJN SNX TEORI TSPGW XIF --K -Q- .55 .GJ 1B1 1OC 31~ 3O- 3V. 4G. 53G 5VS 7X7 88E 8FI 8FJ AAEDT AALRI AAQFI AAQQT AAQXK AAXUO AAYOK AAYXX ABAWZ ABUWG ACXQS ADMUD ADNKB AEETU AFBPY AFFNX AFKRA AHVBC AI. AJAOE BPHCQ BVXVI CAG CCPQU CITATION COF EMOBN FEDTE FGOYB FYUFA HMCUK HVGLF LH4 LW6 M1P M41 N4W NQ- PQQKQ PROAC PSQYO R2- ROL RPZ SSZ SV3 UDS UKHRP VH1 X7M XPP ZGI ZXP ZZMQN K9. 7X8 |
| ID | FETCH-LOGICAL-c267t-929f50e423b93a21d09678989e397ca57390ebe292bc64f3fd88d4db33eb22c73 |
| ISSN | 0002-9270 1572-0241 |
| IngestDate | Sat Oct 26 02:03:07 EDT 2024 Thu Oct 10 21:09:02 EDT 2024 Wed Oct 09 16:48:20 EDT 2024 Sat Nov 02 12:32:12 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Language | English |
| License | Copyright © 2024 by The American College of Gastroenterology. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c267t-929f50e423b93a21d09678989e397ca57390ebe292bc64f3fd88d4db33eb22c73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-4823-5805 0000-0001-6177-3128 0000-0003-1602-4341 0000-0001-6428-3271 0009-0009-7865-6599 0000-0002-1964-010 0000-0001-6472-249 0000-0002-1880-7991 0000-0002-5587-7964 0000-0003-4901-6575 0000-0001-7631-9665 0000-0001-5058-5527 0000-0002-9023-4948 0000-0001-9796-9982 0000-0002-1964-010X 0000-0001-6472-249X |
| PMID | 38275248 |
| PQID | 3075007938 |
| PQPubID | 2041977 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_2925032310 proquest_journals_3075007938 crossref_primary_10_14309_ajg_0000000000002674 pubmed_primary_38275248 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-07-01 |
| PublicationDateYYYYMMDD | 2024-07-01 |
| PublicationDate_xml | – month: 07 year: 2024 text: 2024-07-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: New York |
| PublicationTitle | The American journal of gastroenterology |
| PublicationTitleAlternate | Am J Gastroenterol |
| PublicationYear | 2024 |
| Publisher | Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins |
| Publisher_xml | – name: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins |
| References | Berinstein (R9-20241008) 2019; 17 Berinstein (R10-20241008) 2021; 19 Turner (R1-20241008) 2007; 5 Mohamed (R13-20241008) 2019; 21 Truelove (R12-20241008) 1974; 1 Berinstein (R5-20241008) 2023; 39 Govani (R4-20241008) 2020; 65 Burr (R8-20241008) 2021; 71 Williams (R14-20241008) 2016; 1 Steenholdt (R11-20241008) 2023; 17 Järnerot (R3-20241008) 2005; 128 Lichtiger (R2-20241008) 1994; 330 Laharie (R15-20241008) 2012; 380 Loftus (R6-20241008) 2023; 21 Danese (R7-20241008) 2022; 399 |
| References_xml | – volume: 19 start-page: 2112 issue: 10 year: 2021 ident: R10-20241008 article-title: Tofacitinib for biologic-experienced hospitalized patients with acute severe ulcerative colitis: A retrospective case-control study publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2021.05.038 contributor: fullname: Berinstein – volume: 71 start-page: 1976 issue: 10 year: 2021 ident: R8-20241008 article-title: Efficacy of biological therapies and small molecules in moderate to severe ulcerative colitis: Systematic review and network meta-analysis publication-title: Gut. doi: 10.1136/gutjnl-2021-326390 contributor: fullname: Burr – volume: 1 start-page: 15 issue: 1 year: 2016 ident: R14-20241008 article-title: Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): A mixed methods, open-label, pragmatic randomised trial publication-title: Lancet Gastroenterol Hepatol doi: 10.1016/S2468-1253(16)30003-6 contributor: fullname: Williams – volume: 5 start-page: 103 issue: 1 year: 2007 ident: R1-20241008 article-title: Response to corticosteroids in severe ulcerative colitis: A systematic review of the literature and a meta-regression publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2006.09.033 contributor: fullname: Turner – volume: 21 start-page: 108 issue: 6 year: 2019 ident: R13-20241008 article-title: Development of in vitro–in vivo correlation for upadacitinib extended-release tablet formulation publication-title: AAPS J doi: 10.1208/s12248-019-0378-y contributor: fullname: Mohamed – volume: 128 start-page: 1805 issue: 7 year: 2005 ident: R3-20241008 article-title: Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: A randomized, placebo-controlled study publication-title: Gastroenterology doi: 10.1053/j.gastro.2005.03.003 contributor: fullname: Järnerot – volume: 17 start-page: 988 issue: 5 year: 2019 ident: R9-20241008 article-title: Efficacy of induction therapy with high-intensity tofacitinib in 4 patients with acute severe ulcerative colitis publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2018.11.022 contributor: fullname: Berinstein – volume: 330 start-page: 1841 issue: 26 year: 1994 ident: R2-20241008 article-title: Cyclosporine in severe ulcerative colitis refractory to steroid therapy publication-title: N Engl J Med doi: 10.1056/NEJM199406303302601 contributor: fullname: Lichtiger – volume: 39 start-page: 274 issue: 4 year: 2023 ident: R5-20241008 article-title: In-hospital management of inflammatory bowel disease publication-title: Curr Opin Gastroenterol doi: 10.1097/MOG.0000000000000953 contributor: fullname: Berinstein – volume: 17 start-page: 1354 issue: 8 year: 2023 ident: R11-20241008 article-title: Tofacitinib for acute severe ulcerative colitis: A systematic review publication-title: J Crohns Colitis doi: 10.1093/ecco-jcc/jjad036 contributor: fullname: Steenholdt – volume: 380 start-page: 1909 issue: 9857 year: 2012 ident: R15-20241008 article-title: Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: A parallel, open-label randomised controlled trial publication-title: Lancet Lond Engl doi: 10.1016/S0140-6736(12)61084-8 contributor: fullname: Laharie – volume: 65 start-page: 1800 issue: 6 year: 2020 ident: R4-20241008 article-title: Use of accelerated induction strategy of infliximab for ulcerative colitis in hospitalized patients at a tertiary care center publication-title: Dig Dis Sci doi: 10.1007/s10620-019-05957-0 contributor: fullname: Govani – volume: 399 start-page: 2113 issue: 10341 year: 2022 ident: R7-20241008 article-title: Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: Results from three phase 3, multicentre, double-blind, randomised trials publication-title: Lancet Lond Engl doi: 10.1016/S0140-6736(22)00581-5 contributor: fullname: Danese – volume: 21 start-page: 2347 issue: 9 year: 2023 ident: R6-20241008 article-title: Upadacitinib therapy reduces ulcerative colitis symptoms as early as day 1 of induction treatment publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2022.11.029 contributor: fullname: Loftus – volume: 1 start-page: 1067 issue: 7866 year: 1974 ident: R12-20241008 article-title: Intensive intravenous regimen for severe attacks of ulcerative colitis publication-title: Lancet Lond Engl doi: 10.1016/S0140-6736(74)90552-2 contributor: fullname: Truelove |
| SSID | ssj0015275 |
| Score | 2.523223 |
| Snippet | A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy.
Patients with ASUC treated with upadacitinib and... INTRODUCTION: A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy. METHODS: Patients with ASUC treated with... INTRODUCTION:A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy.METHODS:Patients with ASUC treated with... A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy.INTRODUCTIONA significant proportion of patients with acute... |
| SourceID | proquest crossref pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1421 |
| SubjectTerms | Endoscopy Hospitals Inflammatory bowel disease Patients Remission (Medicine) Steroids Systematic review Tumor necrosis factor-TNF |
| Title | Effectiveness of Upadacitinib for Patients With Acute Severe Ulcerative Colitis: A Multicenter Experience |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38275248 https://www.proquest.com/docview/3075007938 https://www.proquest.com/docview/2925032310 |
| Volume | 119 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgk6a9IO50DGQkXjM6O7fyVgZoohpC0Iq9RbbjVJkgrZrsZb-ez5dcOnUS0IeoitWk8flif-f4nM-EvIWdcxBhGURCRQFm6CSQmPiCVKdcqngsuJVdvPgany_CL5fRZZ-raqtLGnmibnbWlfyPVXEOdjVVsv9g2e6iOIHvsC-OsDCOf2VjJz3cjlegfYu1yIUqm7IqpU0g_OZkU02Wq1meUSYr4IfGg4Jt_lLay36f2SS42lWp25Jck7Np0j86IeQhiZ331SjVUHpiKepms7K_3ArWfzAlhnW7raavHeuDqDOxsXFoFzzo17Qan0BQlXUXs_5o9hhaOpgNM_593IKFXY4rph0_1iYsQMPpzpE85FYJVVwtncSk_7DYbeozsO76tzUvT1kSMSfbeUtCu226T_YZxiMMhPvT2fefs265KUK7L-8y9323666H5KC9zjaHucMxsQRl_pA88J4FnTqYPCL3dPWYHFz43IknpNxCC10VdIgWCrTQFi3UoIVatFCHFtqjhXq0vKdTOsAK7bHylCw-f5qfnQd-o41A4cmaABS5iMYazFpOuGCnOfzaxOwrqsFWlYgSPhnjZWcThtc3LHiRp2ke5pJzLRlTCX9G9qpVpV8QOknHRSqVBGuMwgK-P4sxg4InFVzC845H5KTtumzt9FQy44eabs_Q7dntbh-R47aDM4_oOuOG6Bppx3RE3nTNGBjNapeo9Oq6zvBvozE37suIPHeG6e7YGvLozpaX5LAH7THZazbX-hXoZyNfe_D8AQqyg2s |
| link.rule.ids | 315,783,787,27936,27937 |
| linkProvider | Library Specific Holdings |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effectiveness+of+Upadacitinib+for+Patients+With+Acute+Severe+Ulcerative+Colitis%3A+A+Multicenter+Experience&rft.jtitle=The+American+journal+of+gastroenterology&rft.au=Berinstein%2C+Jeffrey+A&rft.au=Karl%2C+Taylor&rft.au=Patel%2C+Anish&rft.au=Dolinger%2C+Michael&rft.date=2024-07-01&rft.eissn=1572-0241&rft_id=info:doi/10.14309%2Fajg.0000000000002674&rft_id=info%3Apmid%2F38275248&rft.externalDocID=38275248 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9270&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9270&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9270&client=summon |