Relationship between reduced nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene polymorphism and obstructive sleep apnea-hypopnea syndrome in the Chinese Han population

• Published in: Chinese medical journal Vol. 122; no. 12; pp. 1369 - 1374
• Main Authors: Liu, Hui-Guo, Liu, Kui, Zhou, Yan-Ning, Xu, Yong-Jian
• Format: Journal Article
• Language: English
• Published: China Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Key Laboratory of Respiratory Disease, Ministry of Health,Wuhan, Hubei 430030, China 20.06.2009
• Subjects: Adult; Aged; Asian Continental Ancestry Group - genetics; Blood Pressure - genetics; Body Mass Index; China - epidemiology; Genetic Predisposition to Disease; Humans; Male; Middle Aged; NADPH Oxidases - genetics; NADPH氧化酶; p22phox亚基; Polymorphism, Genetic - genetics; Reverse Transcriptase Polymerase Chain Reaction; Sleep Apnea, Obstructive - genetics; Waist-Hip Ratio; Young Adult; 二核苷酸; 基因多态性检测; 汉族人群; 睡眠呼吸暂停综合征; 腺嘌呤; 阻塞性睡眠呼吸暂停; obstructive sleep apnea syndrome; polymorphism; reduced nicotinamide adenine dinucleotide phosphate oxidase; p22phox gene
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2009.12.003

Background Increased production of reactive oxygen species （ROS） is thought to play a major role in the pathogenesis of obstructive sleep apnea-hypopnea syndrome （OSAHS）. The reduced nicotinamide adenine dinucleotide phosphate （NADPH） oxidase complex is an important source of ROS. The p22phox subuni...