Effect of withdrawal of somatostatin and growth hormone (GH)-releasing factor on GH release in vitro

• Published in: Endocrinology (Philadelphia) Vol. 122; no. 5; p. 1810
• Main Authors: Kraicer, J, Sheppard, M S, Luke, J, Lussier, B, Moor, B C, Cowan, J S
• Format: Journal Article
• Language: English
• Published: United States 01.05.1988
• Subjects: Animals; Growth Hormone - secretion; Growth Hormone-Releasing Hormone - pharmacology; In Vitro Techniques; Kinetics; Male; Pituitary Gland - drug effects; Pituitary Gland - secretion; Rats; Recombinant Proteins - pharmacology; Somatostatin - pharmacology

The secretion of GH, in vivo, is pulsatile. We have proposed that the timing of the episodic bursts of GH secretion is set by somatostatin (SRIF) withdrawal, while the magnitude of the bursts is set by the amount of GH-releasing factor (GRF) impinging on the somatotrophs, before and during SRIF with...