Bringing amines back into aziridination

Aziridines — three-membered nitrogen-containing heterocycles — are important synthetic targets, but N -alkyl aziridines are difficult to synthesize. Now, an electrochemical method, involving a dicationic intermediate, enables the coupling of alkenes and amines.

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Published inNature chemistry Vol. 13; no. 11; pp. 1027 - 1028
Main Authors Piou, Tiffany, Campeau, Louis-Charles
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.11.2021
Nature Publishing Group
Subjects
639/638/161
639/638/549/933
Alkenes
Amines
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Commodities
Electrochemistry
Inorganic Chemistry
Natural products
News & Views
news-and-views
Nitrogen
Organic Chemistry
Physical Chemistry
R&D
Research & development
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Abstract Aziridines — three-membered nitrogen-containing heterocycles — are important synthetic targets, but N -alkyl aziridines are difficult to synthesize. Now, an electrochemical method, involving a dicationic intermediate, enables the coupling of alkenes and amines.
AbstractList Aziridines — three-membered nitrogen-containing heterocycles — are important synthetic targets, but N-alkyl aziridines are difficult to synthesize. Now, an electrochemical method, involving a dicationic intermediate, enables the coupling of alkenes and amines.
Aziridines — three-membered nitrogen-containing heterocycles — are important synthetic targets, but N -alkyl aziridines are difficult to synthesize. Now, an electrochemical method, involving a dicationic intermediate, enables the coupling of alkenes and amines.
Author Campeau, Louis-Charles
Piou, Tiffany
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10.1039/B006015L
10.1038/s41586-019-0982-0
10.1021/ja0172215
10.1021/ja028253a
10.1021/acs.chemrev.7b00397
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Snippet Aziridines — three-membered nitrogen-containing heterocycles — are important synthetic targets, but N -alkyl aziridines are difficult to synthesize. Now, an...
Aziridines — three-membered nitrogen-containing heterocycles — are important synthetic targets, but N-alkyl aziridines are difficult to synthesize. Now, an...
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SubjectTerms 639/638/161
639/638/549/933
Alkenes
Amines
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Commodities
Electrochemistry
Inorganic Chemistry
Natural products
News & Views
news-and-views
Nitrogen
Organic Chemistry
Physical Chemistry
R&D
Research & development
Title Bringing amines back into aziridination
URI https://link.springer.com/article/10.1038/s41557-021-00819-7
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