Cdk1: Unsung Hero of S Phase?

• Published in: Cell cycle (Georgetown, Tex.) Vol. 3; no. 4; pp. 399 - 401
• Main Authors: Pacek, Marcin, Prokhorova, Tanya A., Walter, Johannes C.
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 02.04.2004
• Subjects: Binding; Biology; Bioscience; Calcium; Cancer; Cell; Cycle; Landes; Organogenesis; Proteins

Cdk2 has been viewed as a key cell cycle regulator that is essential for S phase progression. The recent discovery that Cdk2 is not required for cell proliferation in mice now shows that other factors must be able to replace Cdk2 in stimulating DNA replication. Experiments performed in Xenopus egg e...