Physiologically-based pharmacokinetic analysis of benzoic acid in rats, guinea pigs and humans: Implications for dietary exposures and interspecies uncertainty

• Published in: Computational toxicology Vol. 3; pp. 19 - 32
• Main Authors: Hoffman, Timothy E., Hanneman, William H.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2017
• Subjects: Benzoic acid; Exposure assessment; Food additive; Ingredient safety; Metabolism; PBPK; Benzoic acid; Ingredient safety; PBPK; Food additive; Metabolism; Exposure assessment

•Multi-species PBPK models have been developed and validated by experimental data.•Repeated, dietarily-relevant oral doses were assessed to predict internal exposures.•Humans see less benzoic acid compared to rats due to faster metabolism/excretion.•These comparisons present very little pharmacokine...