IL-6-STAT3 Controls Intracellular MHC Class II αβ Dimer Level through Cathepsin S Activity in Dendritic Cells

• Published in: Immunity (Cambridge, Mass.) Vol. 23; no. 5; pp. 491 - 502
• Main Authors: Kitamura, Hidemitsu, Kamon, Hokuto, Sawa, Shin-ichiro, Park, Sung-Joo, Katunuma, Nobuhiko, Ishihara, Katsuhiko, Murakami, Masaaki, Hirano, Toshio
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.11.2005

We found IL-6-STAT3 pathway suppresses MHC class II (MHCII) expression on dendritic cells (DCs) and attenuates T cell activation. Here, we showed that IL-6-STAT3 signaling reduced intracellular MHCII αβ dimmer, Ii, and H2-DM levels in DCs. IL-6-mediated STAT3 activation decreased cystatin C level, a...