Parental Consanguinity and Family History in Relation to Psoriasis and the Role of Sex: A Case-Control Study

• Published in: Human heredity Vol. 90; no. 1; pp. 1 - 9
• Main Authors: AlKhas, Alanood N., Ziyab, Ali H.
• Format: Journal Article
• Language: English
• Published: Switzerland S. Karger AG 01.01.2025
• Subjects: Adult; Case-Control Studies; Consanguinity; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Odds Ratio; Parents; Psoriasis - epidemiology; Psoriasis - genetics; Risk Factors; Sex Factors; Young Adult; Inbreeding; Consanguinity; Psoriasis; Risk factors

Introduction: Psoriasis is caused by an interplay between intrinsic and extrinsic factors. Parental consanguinity increases homozygosity in the genome of the offspring, which in turn increases disease risk. The association between parental consanguinity and psoriasis in the offspring remains unexplo...