Cumulative meta-analysis and trial sequential analysis of correlation between hOGG1 Ser326Cys polymorphism and the risk of head and neck squamous cell carcinoma

The human 8-oxoguanine glycosylase 1 ( ) Ser326Cys polymorphism has been involved in the risk of head and neck squamous cell carcinoma (HNSCC), but the results of published studies on this topic still inconsistent. Finally 11 qualified publications with 13 independent case-control studies were yield...

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Published inOncotarget Vol. 9; no. 16; pp. 13077 - 13087
Main Authors Yan, Yan, Deng, Ai-Ping, Chen, Wen, Ming, Yu-Hua, Zeng, Xian-Tao, Leng, Wei-Dong
Format Journal Article
LanguageEnglish
Published United States Impact Journals LLC 27.02.2018
Subjects
Meta-Analysis
human 8-oxoguanine glycosylase 1
meta-analysis
polymorphism
hOGG1
head and neck squamous cell carcinoma
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Abstract The human 8-oxoguanine glycosylase 1 ( ) Ser326Cys polymorphism has been involved in the risk of head and neck squamous cell carcinoma (HNSCC), but the results of published studies on this topic still inconsistent. Finally 11 qualified publications with 13 independent case-control studies were yielded. Overall, we observed significant differences in CysCys vs. SerSer [odds ratio (OR) = 1.55, 95% confidence interval (95% CI) = 1.01-2.38] and CysCys vs. SerCys+SerSer (OR = 1.42, 95% CI = 1.005-1.99) genetic models. Sensitivity analyses showed the results were not robust, cumulative meta-analyses and trial sequential analysis indicated the results didn't not need more studies to identification. Subgroup analyses showed there was a significant association in Caucasian, laryngeal squamous cell carcinoma, studies agreement with Hardy-Weinberg equilibrium, and alcohol drinkers subgroups under the corresponding contrasts. In addition, the results of Egger's test were contradictory. All eligible studies were searched from the online databases including PubMed, Web of Science, China Knowledge Resource Integrated Database, and Wanfang databases up to February 10, 2017. After study selection and data extraction, the meta-analysis was performed using STATA 12.0 software and TSA software version 0.9 Beta. Our meta-analysis results indicated that Ser326Cys polymorphism may be associated with increased risk of HNSCC, especially in Caucasians, alcohol drinkers and the patients with laryngeal squamous cell carcinoma.
AbstractList The human 8-oxoguanine glycosylase 1 (hOGG1) Ser326Cys polymorphism has been involved in the risk of head and neck squamous cell carcinoma (HNSCC), but the results of published studies on this topic still inconsistent.BACKGROUNDThe human 8-oxoguanine glycosylase 1 (hOGG1) Ser326Cys polymorphism has been involved in the risk of head and neck squamous cell carcinoma (HNSCC), but the results of published studies on this topic still inconsistent.Finally 11 qualified publications with 13 independent case-control studies were yielded. Overall, we observed significant differences in CysCys vs. SerSer [odds ratio (OR) = 1.55, 95% confidence interval (95% CI) = 1.01-2.38] and CysCys vs. SerCys+SerSer (OR = 1.42, 95% CI = 1.005-1.99) genetic models. Sensitivity analyses showed the results were not robust, cumulative meta-analyses and trial sequential analysis indicated the results didn't not need more studies to identification. Subgroup analyses showed there was a significant association in Caucasian, laryngeal squamous cell carcinoma, studies agreement with Hardy-Weinberg equilibrium, and alcohol drinkers subgroups under the corresponding contrasts. In addition, the results of Egger's test were contradictory.RESULTSFinally 11 qualified publications with 13 independent case-control studies were yielded. Overall, we observed significant differences in CysCys vs. SerSer [odds ratio (OR) = 1.55, 95% confidence interval (95% CI) = 1.01-2.38] and CysCys vs. SerCys+SerSer (OR = 1.42, 95% CI = 1.005-1.99) genetic models. Sensitivity analyses showed the results were not robust, cumulative meta-analyses and trial sequential analysis indicated the results didn't not need more studies to identification. Subgroup analyses showed there was a significant association in Caucasian, laryngeal squamous cell carcinoma, studies agreement with Hardy-Weinberg equilibrium, and alcohol drinkers subgroups under the corresponding contrasts. In addition, the results of Egger's test were contradictory.All eligible studies were searched from the online databases including PubMed, Web of Science, China Knowledge Resource Integrated Database, and Wanfang databases up to February 10, 2017. After study selection and data extraction, the meta-analysis was performed using STATA 12.0 software and TSA software version 0.9 Beta.MATERIALS AND METHODSAll eligible studies were searched from the online databases including PubMed, Web of Science, China Knowledge Resource Integrated Database, and Wanfang databases up to February 10, 2017. After study selection and data extraction, the meta-analysis was performed using STATA 12.0 software and TSA software version 0.9 Beta.Our meta-analysis results indicated that hOGG1 Ser326Cys polymorphism may be associated with increased risk of HNSCC, especially in Caucasians, alcohol drinkers and the patients with laryngeal squamous cell carcinoma.CONCLUSIONSOur meta-analysis results indicated that hOGG1 Ser326Cys polymorphism may be associated with increased risk of HNSCC, especially in Caucasians, alcohol drinkers and the patients with laryngeal squamous cell carcinoma.
The human 8-oxoguanine glycosylase 1 ( ) Ser326Cys polymorphism has been involved in the risk of head and neck squamous cell carcinoma (HNSCC), but the results of published studies on this topic still inconsistent. Finally 11 qualified publications with 13 independent case-control studies were yielded. Overall, we observed significant differences in CysCys vs. SerSer [odds ratio (OR) = 1.55, 95% confidence interval (95% CI) = 1.01-2.38] and CysCys vs. SerCys+SerSer (OR = 1.42, 95% CI = 1.005-1.99) genetic models. Sensitivity analyses showed the results were not robust, cumulative meta-analyses and trial sequential analysis indicated the results didn't not need more studies to identification. Subgroup analyses showed there was a significant association in Caucasian, laryngeal squamous cell carcinoma, studies agreement with Hardy-Weinberg equilibrium, and alcohol drinkers subgroups under the corresponding contrasts. In addition, the results of Egger's test were contradictory. All eligible studies were searched from the online databases including PubMed, Web of Science, China Knowledge Resource Integrated Database, and Wanfang databases up to February 10, 2017. After study selection and data extraction, the meta-analysis was performed using STATA 12.0 software and TSA software version 0.9 Beta. Our meta-analysis results indicated that Ser326Cys polymorphism may be associated with increased risk of HNSCC, especially in Caucasians, alcohol drinkers and the patients with laryngeal squamous cell carcinoma.
Author Ming, Yu-Hua
Yan, Yan
Zeng, Xian-Tao
Deng, Ai-Ping
Leng, Wei-Dong
Chen, Wen
AuthorAffiliation 1 Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
3 Department of Radiology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
2 Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
AuthorAffiliation_xml – name: 1 Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
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Keywords human 8-oxoguanine glycosylase 1
meta-analysis
polymorphism
hOGG1
head and neck squamous cell carcinoma
Language English
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Snippet The human 8-oxoguanine glycosylase 1 ( ) Ser326Cys polymorphism has been involved in the risk of head and neck squamous cell carcinoma (HNSCC), but the results...
The human 8-oxoguanine glycosylase 1 (hOGG1) Ser326Cys polymorphism has been involved in the risk of head and neck squamous cell carcinoma (HNSCC), but the...
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SubjectTerms Meta-Analysis
Title Cumulative meta-analysis and trial sequential analysis of correlation between hOGG1 Ser326Cys polymorphism and the risk of head and neck squamous cell carcinoma
URI https://www.ncbi.nlm.nih.gov/pubmed/29560133
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https://pubmed.ncbi.nlm.nih.gov/PMC5849197
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