Stearoyl-coenzyme A desaturase enhances cell survival in human uterine leiomyoma

• Published in: F&S Science (Online) Vol. 6; no. 2; p. 202
• Main Authors: Komorowski, Allison S, Coon V, John S, Anton, Melania, Zuberi, Azna, Sotos, Olivia, Bulun, Serdar E, Yin, Ping
• Format: Journal Article
• Language: English
• Published: United States 01.05.2025
• Subjects: Adult; Apoptosis - drug effects; Cell Line, Tumor; Cell Survival - drug effects; Female; Humans; Leiomyoma - enzymology; Leiomyoma - genetics; Leiomyoma - metabolism; Leiomyoma - pathology; Myometrium - metabolism; Stearoyl-CoA Desaturase - antagonists & inhibitors; Stearoyl-CoA Desaturase - genetics; Stearoyl-CoA Desaturase - metabolism; Uterine Neoplasms - enzymology; Uterine Neoplasms - genetics; Uterine Neoplasms - metabolism; Uterine Neoplasms - pathology; Uterine leiomyoma; cell survival; stearoyl-CoA desaturase; progesterone receptor; lipid metabolism
• ISSN: 2666-335X
• DOI: 10.1016/j.xfss.2025.01.005

Stearoyl-CoA desaturase (SCD1) is an enzyme that catalyzes the conversion of saturated delta-9 fatty acids to monounsaturated fatty acids. SCD1 is highly expressed in various cancers and facilitates cancer cell survival, tumor growth, and metastasis. This study aimed to assess SCD1 expression and fu...